Dynamic magnetic resonance imaging of the metacarpophalangeal joints in rheumatoid arthritis, early unclassified polyarthritis, and healthy controls
Dynamic magnetic resonance imaging of the metacarpophalangeal joints in rheumatoid arthritis, early unclassified polyarthritis, and healthy controls
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类风湿关节炎、早期未分类多关节炎和健康对照掌指关节的动态磁共振成像
DOI：
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发表时间：
2000
影响因子：
2.1
通讯作者：
I. Lorenzen
中科院分区：
文献类型：
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作者：
M. Klarlund;M. Østergaard;E. Rostrup;H. Skjødt;I. Lorenzen
Objective.介绍动态磁共振成像（MRI）作为类风湿性关节炎（RA）或早期未分类多发性关节炎患者掌指关节（MCP）炎症活动的指标，并与健康对照组的结果进行比较。材料和方法。我们在一项横断面研究中检查了42例RA和23例早期未分类的多发性关节炎患者，以及12例健康对照。通过第2至第5 MCP关节进行动态MRI（注射造影剂后重复FLASH-MR图像）。比较了两种用于识别增强滑膜的方法：1）在减影图像上勾画增强滑膜和2）通过主成分分析（PCA）自动识别。早期增强率（EE）按前一种方法计算。结果方法1）和2）密切相关（P<0.00001）。从健康对照组，为第2至第5个MCP关节建立正常增强的上限（平均值± 2SD），用于识别患者相应关节中的异常EE率。第2 ~ 5关节EE发生率明显高于健康对照组（P<0.01）。两组间差异无统计学意义（P>0.09）。结论PCA似乎是一种很有前途的自动识别增强组织的方法。手指关节的EE率可能有助于评估RA和早期未分类多发性关节炎患者关节的炎症活动，并可能反映疾病活动的其他方面，而不是临床评估。
Objective. To introduce dynamic magnetic resonance imaging (MRI) as an indicator of inflammatory activity in the metacarpophalangeal (MCP) joints of patients with rheumatoid arthritis (RA) or early unclassified polyarthritis, and to compare the results with a healthy control group. Materials and Methods. We examined 42 RA and 23 early unclassified polyarthritis patients, and 12 healthy controls in a cross-sectional study. Dynamic MRI (repeated FLASH-MR images after injection of a contrast agent) was performed through the 2nd to the 5th MCP joint. Two methods for identification of the enhancing synovial membrane were compared: 1) outlining of enhancing synovial membrane on subtraction images and 2) automated recognition by principal component analysis (PCA). The early enhancement (EE) rate was calculated on the basis of the first method. Results. Method 1) and 2) were closely associated (P<0.00001). From the healthy control group, an upper limit (mean+2SD) of normal enhancement was established for the 2nd to 5th MCP joints, which served to identify abnormal EE rates in the corresponding joints of patients. The patients had higher EE rates in the 2nd to 5th MCP joints than had the healthy controls (P<0.01). There were no significant differences between the two patient groups (P>0.09). Conclusion. PCA seems to be a promising method for automated identification of enhancing tissue. EE rates of the finger joints may be useful in the assessment of the inflammatory activity in the joints of patients with RA and early unclassified polyarthritis and may reflect other aspects of disease activity than clinical evaluation.
碘化物滑膜清除率低提供了慢性类风湿滑膜炎灌注不足的证据。
影响因子：
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作者：
Wallis,WJ;Simkin,PA;Nelp,WB
通讯作者：
Nelp,WB
使用荧光光学成像对类风湿关节炎患者的滑膜炎的定量评估。
影响因子：
4.9
作者：
Schäfer VS;Hartung W;Hoffstetter P;Berger J;Stroszczynski C;Müller M;Fleck M;Ehrenstein B
通讯作者：
Ehrenstein B