Low synovial clearance of iodide provides evidence of hypoperfusion in chronic rheumatoid synovitis.

Low synovial clearance of iodide provides evidence of hypoperfusion in chronic rheumatoid synovitis.
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碘化物滑膜清除率低提供了慢性类风湿滑膜炎灌注不足的证据。

DOI:
10.1002/art.1780281004
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发表时间:
1985
影响因子:
--
通讯作者:
Nelp,WB
Nelp,WB
中科院分区:
--
文献类型:
--
作者:
Wallis,WJ;Simkin,PA;Nelp,WB

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对11例类风湿性关节炎和9例骨关节炎患者的慢性膝关节积液进行了碘清除率测定。类风湿性关节炎积液中的平均(±SE)碘清除率为1.92 ± 0.30 ml/min,与骨关节炎积液中的2.19 ± 0.52 ml/min无显著差异。类风湿性关节炎患者的清除率值范围很广(0.79-3.22 ml/min)。这些患者的碘清除率与滑液(SF)pH值直接相关(r = 0.731,P = 0.005),SF葡萄糖:血清葡萄糖比率(r = 0.746,P = 0.004),SF温度(r = 0.878,P = 0.001),间接与SF乳酸(r =-0.782,P = 0.002)和SF中性粒细胞百分比(r =-0.581,P = 0.03)相关。这些关系支持了这样的假设,即类风湿性滑膜炎通常以组织灌注不足为标志,并且“最病态”的类风湿性关节(如生理指标所定义的)是最缺血的。
Iodide clearance was measured in the chronic knee effusions of 11 patients with rheumatoid arthritis and 9 patients with osteoarthritis. The mean (±SE) iodide clearance of 1.92 ± 0.30 ml/minute in rheumatoid arthritis effusions did not differ significantly from the 2.19 ± 0.52 ml/minute found in osteoarthritis effusions. Clearance values in rheumatoid arthritis patients ranged widely (0.79–3.22 ml/minute). Iodide clearance in these patients correlated directly with synovial fluid (SF) pH (r = 0.731,P= 0.005), SF glucose: serum glucose ratio (r = 0.746,P= 0.004), and SF temperature (r = 0.878,P= 0.001), and indirectly with SF lactate (r = −0.782,P= 0.002) and percentage of SF neutrophils (r = −0.581,P= 0.03). These relationships support the hypothesis that rheumatoid synovitis is often marked by tissue hypoperfusion, and that the “sickest” rheumatoid joints (as defined by physiologic indices) are the most ischemic.
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