Quantitative assessment of synovitis in patients with rheumatoid arthritis using fluorescence optical imaging.
Quantitative assessment of synovitis in patients with rheumatoid arthritis using fluorescence optical imaging.
复制标题
使用荧光光学成像对类风湿关节炎患者的滑膜炎的定量评估。
DOI：
10.1186/ar4304
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发表时间：
2013
影响因子：
4.9
通讯作者：
Ehrenstein B
中科院分区：
文献类型：
--
作者：
Schäfer VS;Hartung W;Hoffstetter P;Berger J;Stroszczynski C;Müller M;Fleck M;Ehrenstein B
目的：前瞻性评价荧光光学成像(FOI)对类风湿关节炎(RA)滑膜关节与非滑膜关节的鉴别诊断价值。对活动期类风湿性关节炎(RA)患者进行手的FOI检查，并对临床优势手的5个关节(指Ⅱ、Ⅲ指的腕关节、掌指关节和近指间关节)进行3个时相(S 1~120、S 121~240、S 241~360)的分层定量荧光读数。为了分析滑膜炎对手的整体血流灌注的影响，我们还计算了一个荧光比率(FLRA)，将每个FLRO除以第II指的指甲读数。比较了临床检查、灰阶、彩色多普勒超声或磁共振成像(MRI)所确定的滑膜炎缺失和存在的关节的平均FLRO和FLRA。对18例患者的90个关节进行分析，得到的FLRO范围为4.4~49.0×103，FLRA范围为0.37~2.27。总体而言，基于FLRA的分析显示出比与FLRO相关的分析更高的区分度，显示出2期和3期的最显著差异。以大于1.2的截断值用FOI检测MRI证实的滑膜炎时，3期的灵敏度为26/39(67%)，特异度为31/40(77%)。FOI对类风湿关节炎受试者滑膜炎的可视化具有潜在的应用价值。对于充分的FOI解释，定量分析应基于为第二阶段和第三阶段计算的新的FLRA。
To prospectively evaluate quantitative assessment of fluorescence optical imaging (FOI) for differentiation of synovitic from non-synovitic joints in patients suffering from rheumatoid arthritis (RA). FOI of the hands was performed in patients with active RA, and a stratified quantitative fluorescence readout (FLRO) of 3 phases (1-120 s; 121-240 s; 241-360 s) was generated for 5 individual joints of the clinical predominant hand (carpal joint, metacarpophalangeal and proximal interphalangeal joints of digits II & III). To dissect the effect of the overall perfusion of the hand from the perfusion due to synovitis, a fluorescence ratio (FLRA) was additionally calculated, dividing each FLRO by the readout of the eponychium of digit II. The mean FLRO and FLRA were compared between joints with absent vs. present synovitis determined by clinical examination, grayscale, color Doppler ultrasonography, or magnetic resonance imaging (MRI). The analysis for 90 individual joints from 18 patients yielded FLRO ranging from 4.4 to 49.0 × 103, and FLRAs ranging from 0.37 to 2.27. Overall, the analyses based on the FLRA revealed a higher discrimination than the analyses related to the FLRO, demonstrating most significant differences in phases 2 and 3. A sensitivity of 26/39 (67%) and a specificity of 31/40 (77%) were calculated for FLRA of phase 3 using a cut-off value of more than 1.2 to detect MRI-confirmed synovitis with FOI. FOI has a potential for visualizing synovitis in subjects with RA. For adequate FOI interpretation, quantitative analysis should be based on the novel FLRA calculated for phases 2 and 3.
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影响因子：
--
作者：
Klauser, A;Frauscher, F;ZurNedden, D
通讯作者：
ZurNedden, D
影响因子：
3.5
作者：
Dziekan, Thomas;Weissbach, Carmen;Osele, Ilka
通讯作者：
Osele, Ilka
影响因子：
27.4
作者：
SCOTT, DL;COULTON, BL;POPERT, AJ
通讯作者：
POPERT, AJ
影响因子：
6.7
作者：
Hansch, A;Frey, O;Kaiser, WA
通讯作者：
Kaiser, WA
通过近红外荧光叶酸靶向探针进行关节炎成像。
影响因子：
4.9
作者：
Chen, WT;Mahmood, U;Weissleder, R;Tung, CH
通讯作者：
Tung, CH