ROS in aging Caenorhabditis elegans: damage or signaling?
ROS in aging Caenorhabditis elegans: damage or signaling?
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DOI：
10.1155/2012/608478
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发表时间：
2012
影响因子：
--
通讯作者：
Matthijssens F
中科院分区：
文献类型：
--
作者：
Back P;Braeckman BP;Matthijssens F
对线虫秀丽线虫的研究使人们对衰老的机制和信号通路有了许多深入的了解。在这篇文章中，我们讨论了利用这种模式生物出现的关于活性氧物种(ROS)在衰老过程中作用的最新发现。多年来，氧化应激和损伤的累积一直是衰老过程的主要机制解释，但回顾最近对线虫的研究，这一理论受到质疑。因此，越来越明显的是，ROS不仅仅是氧化代谢的有毒副产品。相反，似乎更有可能的是，严格控制的ROS浓度和氧化还原电位的波动是信号过程的重要中介。因此，我们讨论了一些解释氧化还原信号如何参与衰老的理论，并提供了一些关于线虫代谢中ROS功能和信号的例子。为了了解ROS的作用和氧化还原状态在生理、应激反应、发育和衰老中的作用，越来越需要在体内进行准确和可逆的检测。因此，我们评论了一些检测ROS和氧化还原的方法，重点是在线虫中实现遗传编码的生物传感器。
Many insights into the mechanisms and signaling pathways underlying aging have resulted from research on the nematode Caenorhabditis elegans. In this paper, we discuss the recent findings that emerged using this model organism concerning the role of reactive oxygen species (ROS) in the aging process. The accrual of oxidative stress and damage has been the predominant mechanistic explanation for the process of aging for many years, but reviewing the recent studies in C. elegans calls this theory into question. Thus, it becomes more and more evident that ROS are not merely toxic byproducts of the oxidative metabolism. Rather it seems more likely that tightly controlled concentrations of ROS and fluctuations in redox potential are important mediators of signaling processes. We therefore discuss some theories that explain how redox signaling may be involved in aging and provide some examples of ROS functions and signaling in C. elegans metabolism. To understand the role of ROS and the redox status in physiology, stress response, development, and aging, there is a rising need for accurate and reversible in vivo detection. Therefore, we comment on some methods of ROS and redox detection with emphasis on the implementation of genetically encoded biosensors in C. elegans.
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影响因子：
29
作者：
Cochemé HM;Quin C;McQuaker SJ;Cabreiro F;Logan A;Prime TA;Abakumova I;Patel JV;Fearnley IM;James AM;Porteous CM;Smith RA;Saeed S;Carré JE;Singer M;Gems D;Hartley RC;Partridge L;Murphy MP
通讯作者：
Murphy MP
影响因子：
7.4
作者：
Back, Patricia;De Vos, Winnok H.;Braeckman, Bart P.
通讯作者：
Braeckman, Bart P.
影响因子：
29
作者：
Albrecht, Simone C.;Barata, Ana Gomes;Dick, Tobias P.
通讯作者：
Dick, Tobias P.
影响因子：
5.4
作者：
Brys K;Castelein N;Matthijssens F;Vanfleteren JR;Braeckman BP
通讯作者：
Braeckman BP
DOI：
10.1016/j.bbrc.2011.02.079
发表时间：
2011-03-18
影响因子：
3.1
作者：
Carlos Fierro-Gonzalez, Juan;Gonzalez-Barrios, Maria;Swoboda, Peter
通讯作者：
Swoboda, Peter