Rapid suppression and sustained activation of distinct cortical regions for a delayed sensory-triggered motor response.
Rapid suppression and sustained activation of distinct cortical regions for a delayed sensory-triggered motor response.
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DOI：
10.1016/j.neuron.2021.05.005
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发表时间：
2021-07-07
期刊：
影响因子：
16.2
通讯作者：
Petersen CCH
中科院分区：
文献类型：
--
作者：
Esmaeili V;Tamura K;Muscinelli SP;Modirshanechi A;Boscaglia M;Lee AB;Oryshchuk A;Foustoukos G;Liu Y;Crochet S;Gerstner W;Petersen CCH
产生由感觉线索引发的延迟运动反应的神经元机制尚不清楚。在这里，我们使用宽视场钙成像、多区域高密度电生理和时间分辨光遗传学操作，追踪了小鼠将短暂的须刺激转化为延迟舔食的皮层活动的精确序列。须挠曲引起的快速活动对任务表现有两个显著的特征：(1)次级须运动皮层的兴奋增强，表明其在连接须感觉加工和舔动作规划方面起着重要作用；(2)口面部感觉运动皮层活动的短暂性降低，有助于抑制过早舔食。在延迟期，随后广泛的皮层活动与预期运动很大程度上相关，但当这些被考虑在内时，额叶皮层的局部持续活动仍然存在，这对反应期的舔舐是必不可少的。我们的研究结果表明，在延迟的目标定向舔舐中，关键的皮层节点与运动计划的产生和及时执行有关。口腔面部皮层快速抑制反应有助于延迟舔舐，次级须状运动皮层是将须状输入转化为舔舐计划的关键节点。Esmaeili、Tamura等人研究了皮层对一项任务的贡献，在这项任务中，小鼠学会对短暂的须状刺激做出反应，并延迟舔舐以获得奖励。他们发现口面感觉运动皮层的抑制抑制了过早舔舐，而次级运动皮层的兴奋在延迟期维持舔舐计划。
The neuronal mechanisms generating a delayed motor response initiated by a sensory cue remain elusive. Here, we tracked the precise sequence of cortical activity in mice transforming a brief whisker stimulus into delayed licking using wide-field calcium imaging, multiregion high-density electrophysiology, and time-resolved optogenetic manipulation. Rapid activity evoked by whisker deflection acquired two prominent features for task performance: (1) an enhanced excitation of secondary whisker motor cortex, suggesting its important role connecting whisker sensory processing to lick motor planning; and (2) a transient reduction of activity in orofacial sensorimotor cortex, which contributed to suppressing premature licking. Subsequent widespread cortical activity during the delay period largely correlated with anticipatory movements, but when these were accounted for, a focal sustained activity remained in frontal cortex, which was causally essential for licking in the response period. Our results demonstrate key cortical nodes for motor plan generation and timely execution in delayed goal-directed licking. Cortex-wide task-epoch-specific causal neural activity across sensorimotor learning Rapid inhibitory response of orofacial cortex contributes to delay licking Secondary whisker motor cortex is a key node converting whisker input to lick plan Sensory information converges to a focal frontal area critical for delayed response Esmaeili, Tamura, et al. investigate cortical contributions to a task in which mice learn to respond to a brief whisker stimulus with delayed licking for reward. They find suppression of orofacial sensorimotor cortex inhibits premature licking, whereas excitation of secondary motor cortex maintains a lick plan during the delay period.
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影响因子：
16.2
作者：
Chabrol, Francois P.;Blot, Antonin;Mrsic-Flogel, Thomas D.
通讯作者：
Mrsic-Flogel, Thomas D.
影响因子：
56.9
作者：
FUSTER, JM;ALEXANDER, GE
通讯作者：
ALEXANDER, GE
影响因子：
16.2
作者：
Ferezou, Isabelle;Haiss, Florent;Petersen, Carl C. H.
通讯作者：
Petersen, Carl C. H.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
DOI：
10.1073/pnas.0605826103
发表时间：
2006-09-26
影响因子：
11.1
作者：
de Lafuente, Victor;Romo, Ranulfo
通讯作者：
Romo, Ranulfo