Electroconductive biomaterials for cardiac tissue engineering.
Electroconductive biomaterials for cardiac tissue engineering.
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DOI：
10.1016/j.actbio.2021.08.031
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发表时间：
2022-03
影响因子：
9.7
通讯作者：
Nikkhah M
中科院分区：
文献类型：
--
作者：
Esmaeili H;Patino-Guerrero A;Hasany M;Ansari MO;Memic A;Dolatshahi-Pirouz A;Nikkhah M
心肌梗死（MI）仍然是世界范围内死亡的主要原因。由于选择合适的细胞来源、缺乏工程组织和生物材料与宿主心肌的移植、有限的血管性以及注射细胞的不成熟等方面的限制，细胞治疗和组织工程策略治疗损伤心肌的成功受到了明显的阻碍。心脏组织工程（cTE）的第一代方法主要依赖于使用所需细胞（如干细胞）以及非导电的天然或合成生物材料在体外构建和成熟功能性心脏组织，然后在体内测试工程组织的功效。然而，为了更好地概括心肌的固有特性和导电性，最近的方法是在工程心脏组织中使用导电生物材料或纳米材料组件。本文综述了近年来导电生物材料在cTE中的应用进展。具体的重点将放在不同类型的纳米材料的使用，如金纳米颗粒（GNPs），硅衍生的纳米材料，碳基纳米材料（CBNs），以及导电聚合物（ECPs）的工程功能和导电心脏组织。我们还将介绍工程导电组织在体内心脏再生应用中的最新进展。我们将讨论每种方法的机遇和挑战，并就增强cTE的潜在途径提出我们的观点。
Myocardial infarction (MI) is still the leading cause of mortality worldwide. The success of cell-based therapies and tissue engineering strategies for treatment of injured myocardium have been notably hindered due to the limitations associated with the selection of a proper cell source, lack of engraftment of engineered tissues and biomaterials with the host myocardium, limited vascularity, as well as immaturity of the injected cells. The first-generation approaches in cardiac tissue engineering (cTE) have mainly relied on the use of desired cells (e.g., stem cells) along with non-conductive natural or synthetic biomaterials for in vitro construction and maturation of functional cardiac tissues, followed by testing the efficacy of the engineered tissues in vivo. However, to better recapitulate the native characteristics and conductivity of the cardiac muscle, recent approaches have utilized electroconductive biomaterials or nanomaterial components within engineered cardiac tissues. This review article will cover the recent advancements in the use of electrically conductive biomaterials in cTE. The specific emphasis will be placed on the use of different types of nanomaterials such as gold nanoparticles (GNPs), silicon-derived nanomaterials, carbon-based nanomaterials (CBNs), as well as electroconductive polymers (ECPs) for engineering of functional and electrically conductive cardiac tissues. We will also cover the recent progress in the use of engineered electroconductive tissues for in vivo cardiac regeneration applications. We will discuss the opportunities and challenges of each approach and provide our perspectives on potential avenues for enhanced cTE.
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DOI：
10.1002/adma.201503255
发表时间：
2016-01-06
期刊：
Advanced materials (Deerfield Beach, Fla.)
影响因子：
--
作者：
Annabi N;Shin SR;Tamayol A;Miscuglio M;Bakooshli MA;Assmann A;Mostafalu P;Sun JY;Mithieux S;Cheung L;Tang XS;Weiss AS;Khademhosseini A
通讯作者：
Khademhosseini A
影响因子：
14
作者：
Blackburn, Nick J. R.;Sofrenovic, Tanja;Suuronen, Erik J.
通讯作者：
Suuronen, Erik J.
影响因子：
19
作者：
Burnstine-Townley, Alex;Eshel, Yoni;Amdursky, Nadav
通讯作者：
Amdursky, Nadav
影响因子：
14
作者：
Bao, Rui;Tan, Baoyu;Liu, Wenguang
通讯作者：
Liu, Wenguang
影响因子：
9.7
作者：
Ceccaldi, Caroline;Bushkalova, Raya;Fullana, Sophie Girod
通讯作者：
Fullana, Sophie Girod