Effects of light at night on laboratory animals and research outcomes.
Effects of light at night on laboratory animals and research outcomes.
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DOI：
10.1037/bne0000252
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发表时间：
2018-08
影响因子：
1.9
通讯作者：
DeVries AC
中科院分区：
文献类型：
--
作者：
Emmer KM;Russart KLG;Walker WH;Nelson RJ;DeVries AC
光对大多数实验动物的生理和行为有重大影响。因此，动物房间内的照明条件可能很重要，并且在实验中经常被低估的变量。光/暗周期的破坏，主要是通过在夜间将动物暴露在光线 (LAN) 下，扰乱生物节律，并由于褪黑激素抑制、交感神经刺激和生物钟基因表达改变等机制而产生广泛的生理后果。因此，关注实验动物的照明环境并保持光/暗循环的一致性对于研究的可重复性至关重要。光强度以及波长、光周期和时间都是重要的变量。尽管现代啮齿动物设施的设计是为了促进适当的光循环，但有一些简单的方法可以修改房间以防止在黑暗期间暴露于外部光线。研究人员和研究护理人员对实验动物照明条件的关注确保了维持动物福利的最佳实践以及研究结果的可重复性。
Light has substantial influences on the physiology and behavior of most laboratory animals. As such, lighting conditions within animal rooms are potentially significant, and often underappreciated variables within experiments. Disruption of the light/dark cycle, primarily by exposing animals to light at night (LAN), disturbs biological rhythms and has widespread physiological consequences due to mechanisms such as melatonin suppression, sympathetic stimulation, and altered circadian clock gene expression. Thus, attention to the lighting environment of laboratory animals and maintaining consistency of a light/dark cycle is imperative for study reproducibility. Light intensity as well as wavelength, photoperiod, and timing are all important variables. Although modern rodent facilities are designed to facilitate appropriate light cycling, there are simple ways to modify rooms to prevent extraneous light exposure during the dark period. Attention to lighting conditions of laboratory animals by both researchers and research care staff ensures best practices for maintaining animal welfare, as well as reproducibility of research results.
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影响因子：
3.7
作者：
Blask DE;Dauchy RT;Dauchy EM;Mao L;Hill SM;Greene MW;Belancio VP;Sauer LA;Davidson L
通讯作者：
Davidson L
影响因子：
2.8
作者：
Cermakian N;Lange T;Golombek D;Sarkar D;Nakao A;Shibata S;Mazzoccoli G
通讯作者：
Mazzoccoli G
影响因子：
3.5
作者：
Alvarez, J. D.;Hansen, Amanda;Sehgal, Amita
通讯作者：
Sehgal, Amita
影响因子：
2.3
作者：
CLARKE, JA
通讯作者：
CLARKE, JA
影响因子：
2.9
作者：
BRAINARD, GC;RICHARDSON, BA;REITER, RJ
通讯作者：
REITER, RJ