Prenatal exposure to airborne polycyclic aromatic hydrocarbons and risk of intrauterine growth restriction.
Prenatal exposure to airborne polycyclic aromatic hydrocarbons and risk of intrauterine growth restriction.
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DOI：
10.1289/ehp.10958
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发表时间：
2008-05
影响因子：
10.4
通讯作者：
Perera FP
中科院分区：
文献类型：
--
作者：
Choi H;Rauh V;Garfinkel R;Tu Y;Perera FP
多环芳烃（PAHs）是由包括化石燃料在内的有机物燃烧产生的普遍存在的空气污染物。产前暴露于空气污染，特别是多环芳烃，是否会显著增加胎儿宫内生长受限的风险，包括小于胎龄儿（SGA）和早产，这一直是一个悬而未决的问题。在这里，我们在纽约市的一组母亲和新生儿中检验了这一假设。受试者是居住在纽约市的年轻、不吸烟、健康的非裔美国人（n = 224）和多米尼加人（n = 392）母亲-新生儿对，其产前PAH暴露通过个人空气监测进行估计。收集调查问卷和病历资料。产前PAH暴露增加1个自然对数（ln）单位与对称性宫内生长受限风险增加2倍相关（即，足月非裔美国人中SGA和胎儿生长率< 85%）（p < 0.05）。非裔美国人产前PAH暴露每增加1个单位，早产风险增加5倍。在非裔美国人中，相同单位的暴露增加使头围与出生体重的比率显著增加0.04%。多米尼加人没有观察到这些影响。产前PAH暴露可能导致非裔美国人发生SGA以及早产。多米尼加人缺乏相关性可能反映了最近多米尼加移民中健康的文化习俗对风险的影响。鉴于多环芳烃是全球产生和分布的污染物，我们的观察对环境健康和能源政策有潜在的影响。
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous air pollutants generated by combustion of organic material, including fossil fuel. It has been an open question whether prenatal exposure to air pollution in general and PAHs in particular significantly increases the risk of intrauterine growth restriction, including small size for gestational age (SGA), and preterm delivery. Here, we have examined this hypothesis in a cohort of mothers and newborns in New York City. Subjects were young, nonsmoking, healthy African-American (n = 224) and Dominican (n = 392) mother–newborn pairs residing in New York City whose prenatal PAH exposures were estimated by personal air monitoring. Questionnaire and medical record data were obtained. A 1 natural-log (ln)-unit increase in prenatal PAH exposure was associated with a 2-fold increase in risk of symmetric intrauterine growth restriction (i.e., SGA and fetal growth ratio < 85%) among full-term African Americans (p < 0.05). Preterm delivery risk was 5-fold greater among African Americans per ln-unit increase in prenatal PAH exposure. The same unit increase in exposure significantly increased the ratio of head circumference to birth weight by 0.04% in African Americans. These effects were not observed in Dominicans. Prenatal PAH exposure is likely to contribute to the occurrence of SGA as well as preterm births among African Americans. The lack of an association in Dominicans might reflect modification of the risk by healthful cultural practices among recent Dominican immigrants. Given that PAHs are globally generated and distributed pollutants, our observations have potential implications for environmental health and energy policies.
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影响因子：
8
作者：
Boney, CM;Verma, A;Vohr, BR
通讯作者：
Vohr, BR
影响因子：
7.2
作者：
Cedergren, Marie I.
通讯作者：
Cedergren, Marie I.
影响因子：
12.7
作者：
Frisbie, WP;Biegler, M;Pullum, SG
通讯作者：
Pullum, SG
影响因子：
3.3
作者：
Archibong, AE;Inyang, F;Nyanda, AM
通讯作者：
Nyanda, AM
影响因子：
10.4
作者：
Choi, Hyunok;Jedrychowski, Wieslaw;Spengler, John;Camann, David E;Whyatt, Robin M;Rauh, Virginia;Tsai, Wei-Yann;Perera, Frederica P
通讯作者：
Perera, Frederica P