Superhydrophobic materials for tunable drug release: using displacement of air to control delivery rates.
Superhydrophobic materials for tunable drug release: using displacement of air to control delivery rates.
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DOI：
10.1021/ja211148a
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发表时间：
2012-02-01
影响因子：
15
通讯作者：
Grinstaff, Mark W.
中科院分区：
文献类型：
--
作者：
Yohe, Stefan T.;Colson, Yolonda L.;Grinstaff, Mark W.
我们已经从生物相容性构建块中制备了3D超疏水材料，其中空气作为多孔电纺网中的屏障成分，以控制药物释放的速率。具体地，我们制造了含有聚（单硬脂酸甘油酯-共-ε-己内酯）作为疏水聚合物掺杂剂的聚（ε-己内酯）电纺网，这导致高表观接触角网。我们证明，这些网格的表观接触角决定了水渗透到多孔网络和取代截留空气的速率。添加模型生物活性剂（SN-38）显示出释放速率与表观接触角的显著依赖性，这可以通过静电纺丝网内的空气的这种位移来解释。我们进一步表明，多孔的，更高的表面积的电纺网可以制备释放更慢比对照非多孔结构。最后，超疏水网内的截留空气层显示在血清存在下是稳健的，其中载药网在体外对癌细胞有效>60天，因此证明了长期药物递送的适用性。
We have prepared 3D superhydrophobic materials from biocompatible building blocks, where air acts as a barrier component in a porous electrospun mesh to control the rate at which drug is released. Specifically, we fabricated poly(ε-caprolactone) electrospun meshes containing poly(glycerol monostearate-co-ε-caprolactone) as a hydrophobic polymer dopant, which results in high apparent contact angle meshes. We demonstrate that the apparent contact angle of these meshes dictates the rate at which water penetrates into the porous network and displaces entrapped air. Addition of a model bioactive agent (SN-38) shows a release rate with a striking dependence on apparent contact angle which can be explained by this displacement of air within the electrospun meshes. We further show that porous, higher surface area electrospun meshes can be prepared to release more slowly than control non-porous constructs. Finally, the entrapped air layer within superhydrophobic meshes is shown to be robust in the presence of serum, where drug loaded meshes are efficacious against cancer cells in vitro for >60 days, thus demonstrating applicability for long-term drug delivery.
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DOI：
10.1016/j.ejpb.2008.09.021
发表时间：
2009-03
期刊：
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
影响因子：
--
作者：
Kim S;Kim JH;Jeon O;Kwon IC;Park K
通讯作者：
Park K
影响因子：
11.2
作者：
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通讯作者：
Grinstaff, Mark W.
影响因子：
29.4
作者：
Shieh, Jiann;Hou, Fu Ju;Chen, Hsuen Li
通讯作者：
Chen, Hsuen Li
影响因子：
2.5
作者：
Rothenfluh, Dominique A.;Hubbell, Jeffrey A.
通讯作者：
Hubbell, Jeffrey A.
影响因子：
3.9
作者：
Tsai, Peichun;Pacheco, Sergio;Lohse, Detlef
通讯作者：
Lohse, Detlef