A U-shaped association between the triglyceride to high-density lipoprotein cholesterol ratio and the risk of incident type 2 diabetes mellitus in Japanese men with normal glycemic levels: a population-based longitudinal cohort study.
A U-shaped association between the triglyceride to high-density lipoprotein cholesterol ratio and the risk of incident type 2 diabetes mellitus in Japanese men with normal glycemic levels: a population-based longitudinal cohort study.
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DOI：
10.3389/fendo.2023.1180910
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发表时间：
2023
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
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多项研究已证实，高基线 TG/HDL-C 比值是发生 2 型糖尿病 (T2DM) 的危险因素。然而，对于低基线 TG/HDL-C 水平，结果与我们的不一致。此外，对于血糖水平正常的日本男性，基线 TG/HDL-C 比值与 T2DM 发生风险之间的关联尚不清楚。因此，我们的研究进一步调查了血糖水平正常的日本男性基线 TG/HDL-C 与 T2DM 发生风险之间的关系。这是一项二次纵向队列研究。我们从 NAGALA 数据库中选择了 2004 年至 2015 年间的 7,684 名男性参与者。使用标准化 Cox 回归模型和两个分段 Cox 回归模型探讨基线高密度脂蛋白胆固醇比值 (TG/HDL-C) 与 T2DM 发病率之间的关系。在中位随访 2,282 天期间，162 名男性罹患 T2DM。在调整后的模型中，基线 TG/HDL-C 比值与 T2DM 发生风险密切相关，并且在整个基线 TG/HDL-C 四分位数中，未观察到基线 TG/HDL-C 比值与 T2DM 发病率之间存在剂量依赖性正相关关系。两分段线性回归分析显示基线 TG/HDL-C 比值与 T2DM 发病率之间存在 U 形关联。基线 TG/HDL-C 比值低于 1.188 与 T2DM 发病呈负相关（HR = 0.105，95% CI = 0.025、0.451；P = 0.002）。相反，基线 TG/HDL-C 比值 >1.188 与 T2DM 发病呈正相关（HR = 1.248，95% CI = 1.113、1.399；P<0.001）。预测 T2DM 事件的最佳 TG/HDL-C 阈值是 1.8115（曲线下面积，0.6837）。在血糖水平正常的日本男性中，基线 TG/HDL-C 比值与 T2DM 发病率之间存在 U 形关系。
Several studies have verified that a high baseline TG/HDL-C ratio is a risk factor for incident type 2 diabetes mellitus (T2DM). However, for low baseline TG/HDL-C levels, the findings were inconsistent with ours. In addition, the association between baseline TG/HDL-C ratio and the risk of incident T2DM in Japanese men with normal glycemic levels is unclear. As a result, our study further investigated the relationship between baseline TG/HDL-C and the risk of incident T2DM in Japanese men with normal glycemic levels. This was a secondary longitudinal cohort study. We selected 7,684 male participants between 2004 and 2015 from the NAGALA database. A standardized Cox regression model and two piecewise Cox regression models were used to explore the relationship between the baseline high-density lipoprotein cholesterol ratio (TG/HDL-C) and incident T2DM. During a median follow-up of 2,282 days, 162 men developed incident T2DM. In the adjusted model, the baseline TG/HDL-C ratio was strongly associated with the risk of incident T2DM, and no dose-dependent positive association was observed between the baseline TG/HDL-C ratio and incidence of T2DM throughout the baseline TG/HDL-C quartiles. Two-piecewise linear regression analysis showed a U-shaped association between baseline TG/HDL-C ratio and incidence of incident T2DM. A baseline TG/HDL-C ratio below 1.188 was negatively associated with incident T2DM (H.R. = 0.105, 95% CI = 0.025, 0.451; P = 0.002). In contrast, a baseline TG/HDL-C ratio >1.188 was positively associated with incident T2DM (H.R. = 1.248, 95% CI = 1.113, 1.399; P<0.001). The best TG/HDL-C threshold for predicting incident T2DM was 1.8115 (area under the curve, 0.6837). A U-shaped relationship between baseline TG/HDL-C ratio and incident T2DM in Japanese men with normal glycemic levels was found.
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DOI：
10.1126/science.aad3517
发表时间：
2016-03-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Zanoni P;Khetarpal SA;Larach DB;Hancock-Cerutti WF;Millar JS;Cuchel M;DerOhannessian S;Kontush A;Surendran P;Saleheen D;Trompet S;Jukema JW;De Craen A;Deloukas P;Sattar N;Ford I;Packard C;Majumder Aa;Alam DS;Di Angelantonio E;Abecasis G;Chowdhury R;Erdmann J;Nordestgaard BG;Nielsen SF;Tybjærg-Hansen A;Schmidt RF;Kuulasmaa K;Liu DJ;Perola M;Blankenberg S;Salomaa V;Männistö S;Amouyel P;Arveiler D;Ferrieres J;Müller-Nurasyid M;Ferrario M;Kee F;Willer CJ;Samani N;Schunkert H;Butterworth AS;Howson JM;Peloso GM;Stitziel NO;Danesh J;Kathiresan S;Rader DJ;CHD Exome+ Consortium;CARDIoGRAM Exome Consortium;Global Lipids Genetics Consortium
通讯作者：
Global Lipids Genetics Consortium
影响因子：
9.3
作者：
Kim J;Shin SJ;Kim YS;Kang HT
通讯作者：
Kang HT
DOI：
10.1161/atvbaha.107.153858
发表时间：
2008-01-01
影响因子：
8.7
作者：
Frikke-Schmidt, Ruth;Nordestgaard, Borge G.;Tybjaerg-Hansen, Anne
通讯作者：
Tybjaerg-Hansen, Anne
影响因子：
9.3
作者：
Chiang JK;Lai NS;Chang JK;Koo M
通讯作者：
Koo M
影响因子：
4.3
作者：
Liu H;Yan S;Chen G;Li B;Zhao L;Wang Y;Hu X;Jia X;Dou J;Mu Y;Wen J;Lyu Z
通讯作者：
Lyu Z