Association of the Ratio of Triglycerides to High-Density Lipoprotein Cholesterol Levels with the Risk of Type 2 Diabetes: A Retrospective Cohort Study in Beijing.
Association of the Ratio of Triglycerides to High-Density Lipoprotein Cholesterol Levels with the Risk of Type 2 Diabetes: A Retrospective Cohort Study in Beijing.
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DOI：
10.1155/2021/5524728
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发表时间：
2021
影响因子：
4.3
通讯作者：
Lyu Z
中科院分区：
文献类型：
--
作者：
Liu H;Yan S;Chen G;Li B;Zhao L;Wang Y;Hu X;Jia X;Dou J;Mu Y;Wen J;Lyu Z
既往研究表明，甘油三酯与高密度脂蛋白胆固醇水平的比值（TG/HDL-C）是2型糖尿病（T2DM）的危险因素。本研究的目的是探讨中国人群中 TG/HDL-C 与 T2DM 发病率之间的非线性关系。 我们使用逻辑回归模型来估计来自中国糖尿病患者癌症风险评估：一项基线纵向 (REACTION) 队列研究的 7,791 名参与者中 T2DM 发病率的比值比 (OR) 和 95% 置信区间 (CI)。 在调整年龄、性别、体重指数、吸烟状况、酒精摄入量、低密度脂蛋白胆固醇水平、剧烈活动、教育水平、T2DM和肿瘤家族史以及高血压、肿瘤、中风和冠心病的存在后，我们发现TG/HDL-C在4年随访时与T2DM的发病率呈正相关（OR = 1.49，95%CI = 1.26-1.78）。 TG/HDL-C与T2DM发病率呈非线性关系； TG/HDL-C的拐点为1.50。拐点左侧和右侧的 OR (95% CI) 分别为 2.50 (1.70–3.67) 和 0.96 (0.67–1.37)。调整年龄、性别和体重指数（BMI）的线性关系后，T2DM发病率的OR为1.60（95%CI=1.37-1.87）。当TG/HDL-C小于1.50或大于1.76时，OR（95% CI）分别为2.41（1.82-3.18）或0.81（0.53-1.25）。亚组分析显示 T2DM 发病率与性别、BMI、T2DM 家族史或 TG/HDL-C 没有关系。 TG/HDL-C 与糖尿病风险呈正相关。在我们的研究中，随着五分位数的增加，4 年后 T2DM 的风险为 1.60 或 1.49，具体取决于调整的变量。此外，我们的队列研究显示 TG/HDL-C 与 T2DM 发病率之间存在非线性关系，拐点为 1.76 或 1.50，具体取决于调整的变量。当TG/HDL小于1.50时，OR（95% CI）为2.41（1.82-3.18）和2.50（1.70-3.67）。当TG/HDL-C大于1.76或1.50时，OR的变化无显着差异。
Previous studies have shown that the ratio of triglyceride to high-density lipoprotein cholesterol level (TG/HDL-C) is a risk factor for type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the nonlinear relationship between TG/HDL-C and the incidence of T2DM in a Chinese population. We used logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the incidence of T2DM among 7,791 participants from the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) cohort study at baseline. After adjusting for age, sex, body mass index, smoking status, alcohol intake, low-density lipoprotein cholesterol level, strenuous activity, education level, family histories of T2DM and tumors, and the presence of hypertension, tumor, stroke, and coronary heart disease, we showed that TG/HDL-C was positively associated with the incidence of T2DM at the 4-year follow-up (OR = 1.49, 95%CI = 1.26–1.78). TG/HDL-C and incidence of T2DM showed a nonlinear relationship; the inflection point of TG/HDL-C was 1.50. The ORs (95% CI) on the left and right sides of the inflection point were 2.50 (1.70–3.67) and 0.96 (0.67–1.37), respectively. After adjusting for age, sex, and body mass index (BMI) in the linear relationship, the OR of the incidence of T2DM was 1.60 (95%CI = 1.37–1.87). When the TG/HDL-C was less than 1.50 or greater than 1.76, the ORs (95% CI) were 2.41 (1.82–3.18) or 0.81 (0.53–1.25), respectively. Subgroup analysis showed no relationships of T2DM incidence with sex, BMI, family history of T2DM, or TG/HDL-C. TG/HDL-C is positively associated with diabetes risk. In our study, with each increasing quintile, the risk of T2DM after 4 years was 1.60 or 1.49 depending on the variables adjusted. In addition, our cohort study showed a nonlinear relationship between TG/HDL-C and T2DM incidence, with an inflection point of 1.76 or 1.50, depending on the variables adjusted. When the TG/HDL was less than 1.50, the ORs (95% CI) were 2.41 (1.82–3.18) and 2.50 (1.70–3.67). When the TG/HDL-C was greater than 1.76 or 1.50, there was no significant difference in the change in OR.
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