The interaction of animal cytoplasmic RNA viruses with the nucleus to facilitate replication.
The interaction of animal cytoplasmic RNA viruses with the nucleus to facilitate replication.
复制标题
DOI：
10.1016/s0168-1702(03)00160-6
复制
发表时间：
2003-09
期刊：
影响因子：
5
通讯作者：
Hiscox JA
中科院分区：
文献类型：
--
作者：
Hiscox JA
许多主要复制位点是细胞质的正链和负链RNA病毒使用细胞核和/或细胞核成分来促进其复制过程并改变宿主细胞功能。细胞核本身被分为许多不同的子域，包括诸如核仁的结构。定位于这些结构域的许多核蛋白参与RNA加工，并且由于其有限的编码能力，RNA病毒可能需要隔离这些细胞因子以促进其基因组的复制，转录和翻译。其中最好的研究例子是小核糖核酸病毒，其感染导致核蛋白重新分布到细胞质中，并与内部核糖体进入位点（IRES）相互作用，以促进小核糖核酸病毒多蛋白的翻译。可以发现在病毒感染期间定位于细胞核和亚结构域（特别是核仁）的其他正链和负链RNA病毒蛋白的实例，并且已经定义了几种定位基序。除了隔离核蛋白在复制中的作用外，这些病毒还可以靶向细胞核以破坏核功能并抑制抗病毒反应。
A number of positive and negative strand RNA viruses whose primary site of replication is the cytoplasm use the nucleus and/or nuclear components in order to facilitate their replicative processes and alter host cell function. The nucleus itself is divided into a number of different sub-domains including structures such as the nucleolus. Many of the nuclear proteins that localise to these domains are involved in RNA processing, and because of their limited coding capacity, it may be necessary for RNA viruses to sequester such cellular factors in order to facilitate the replication, transcription and translation of their genomes. Amongst the best-studied examples of this are the picornaviruses, whose infection results in the redistribution of nuclear proteins to the cytoplasm and their interaction with the internal ribosome entry site (IRES) to facilitate translation of the picornavirus polyprotein. Examples can be found of other positive and also negative strand RNA virus proteins that localise to the nucleus and sub-domains (especially the nucleolus) during virus infection, and several localisation motifs have been defined. Apart from sequestering nuclear proteins for a role in replication, such viruses may also target the nucleus to disrupt nuclear functions and to inhibit antiviral responses.
登录
查看更多内容
影响因子：
64.5
作者：
Fornerod, M;Ohno, M;Mattaj, IW
通讯作者：
Mattaj, IW
影响因子：
9.2
作者：
Andersen, JS;Lyon, CE;Lamond, AI
通讯作者：
Lamond, AI
DOI：
10.1073/pnas.93.16.8268
发表时间：
1996-08-06
影响因子：
11.1
作者：
DaPoian, AT;Gomes, AM;Silva, JL
通讯作者：
Silva, JL
影响因子：
56.9
作者：
Enninga, J;Levy, DE;Fontoura, BMA
通讯作者：
Fontoura, BMA
DOI：
10.1006/bbrc.1995.1010
发表时间：
1995-01-05
影响因子：
3.1
作者：
ALDABE, R;CARRASCO, L
通讯作者：
CARRASCO, L