The long non-coding RNA ANRIL promotes proliferation and cell cycle progression and inhibits apoptosis and senescence in epithelial ovarian cancer.
The long non-coding RNA ANRIL promotes proliferation and cell cycle progression and inhibits apoptosis and senescence in epithelial ovarian cancer.
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长非编码RNA ANRIL促进上皮性卵巢癌的增殖和细胞周期进程并抑制细胞凋亡和衰老
DOI：
10.18632/oncotarget.8744
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发表时间：
2016-05-31
期刊：
影响因子：
--
通讯作者：
Hua KQ
中科院分区：
文献类型：
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作者：
Qiu JJ;Wang Y;Liu YL;Zhang Y;Ding JX;Hua KQ
INK4基因座的反义非编码RNA(ANRIL)与多种癌症有关。在本研究中，我们评估了ANRIL在上皮性卵巢癌(EOC)中的表达，并确定了其临床意义和生物学功能。ANRIL在上皮性卵巢癌组织中的表达高于正常对照组。过表达与国际妇产科医生联合会分期和高组织学分级相关。多因素分析表明，ANRIL是影响卵巢癌患者总体生存的独立预后因素。功能获得和功能丧失实验表明，ANRIL在体外和体内都能促进EOC细胞的增殖。其增殖作用与促进细胞周期进程、抑制细胞凋亡和衰老有关。ANRIL下调p15INK4b和上调Bcl2可能是ANRIL诱导EoC细胞增殖的部分原因。这项研究首次证实ANRIL促进EOC进展，是一个潜在的预后生物标记物。
Antisense non-coding RNA in the INK4 locus (ANRIL) has been implicated in a variety of cancers. In the present study, we evaluated ANRIL expression in epithelial ovarian cancer (EOC) and defined its clinical implications and biological functions. ANRIL was overexpressed in EOC tissues relative to normal controls. Overexpression correlated with advanced International Federation of Gynecologists and Obstetricians stage and high histological grade. Multivariate analysis indicated that ANRIL is an independent prognostic factor for overall survival in EOC. Gain- and loss-of-function experiments demonstrated that ANRIL promotes EOC cell proliferation both in vitro and in vivo. The proliferative effect was linked to the promotion of cell cycle progression and inhibition of apoptosis and senescence. Down-regulation of P15INK4B and up-regulation of Bcl-2 by ANRIL may partially explain ANRIL-induced EOC cell proliferation. This study is the first to establish that ANRIL promotes EOC progression and is a potential prognostic biomarker.
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影响因子：
64.5
作者：
Huarte M;Guttman M;Feldser D;Garber M;Koziol MJ;Kenzelmann-Broz D;Khalil AM;Zuk O;Amit I;Rabani M;Attardi LD;Regev A;Lander ES;Jacks T;Rinn JL
通讯作者：
Rinn JL
DOI：
10.1038/nrc2644
发表时间：
2009-06
期刊：
Nature reviews. Cancer
影响因子：
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作者：
通讯作者：
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影响因子：
64.8
作者：
通讯作者：
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影响因子：
3.4
作者：
Ge, Xiaosong;Chen, Yuanbin;Jia, Weihua
通讯作者：
Jia, Weihua
影响因子：
30.8
作者：
通讯作者：
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