Identification of a neural basis for cold acclimation in Drosophila larvae.
Identification of a neural basis for cold acclimation in Drosophila larvae.
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DOI：
10.1016/j.isci.2021.102657
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发表时间：
2021-06-25
期刊：
影响因子：
5.8
通讯作者：
Cox DN
中科院分区：
文献类型：
--
作者：
Himmel NJ;Letcher JM;Sakurai A;Gray TR;Benson MN;Donaldson KJ;Cox DN
低温对昆虫来说可能是致命的，但许多物种已经进化出适应寒冷的能力，从而提高了它们的耐寒性。先前已经表明，果蝇幼虫在伤害性冷感受神经元（伤害感受器）的控制下执行冷诱发行为，但尚不清楚神经系统如何参与冷耐受。在此，我们描述了11种果蝇的冷伤害性行为，我们发现，主要的冷诱发幼虫的反应是一个头到尾的收缩行为，这可能是从一个共同的祖先继承，但不太可能是保护。因此，我们测试的假设，冷伤害性功能，以保护幼虫触发冷驯化。我们发现果蝇黑腹果蝇III类伤害性感受器对冷适应敏感且至关重要，并且冷适应可以在没有寒冷的情况下被光遗传学诱发。总的来说，这些研究结果表明，冷伤害感受构成果蝇幼虫冷驯化的外周神经基础。果蝇幼虫通过不明显的保护行为对冷作出反应遗传沉默冷伤害感受器导致不能冷适应冷适应导致伤害感受器过敏冷耐受性可以通过激活冷伤害感受器来提高生物科学;生理学;神经科学;行为神经科学;细胞神经科学;感觉神经科学
Low temperatures can be fatal to insects, but many species have evolved the ability to cold acclimate, thereby increasing their cold tolerance. It has been previously shown that Drosophila melanogaster larvae perform cold-evoked behaviors under the control of noxious cold-sensing neurons (nociceptors), but it is unknown how the nervous system might participate in cold tolerance. Herein, we describe cold-nociceptive behavior among 11 drosophilid species; we find that the predominant cold-evoked larval response is a head-to-tail contraction behavior, which is likely inherited from a common ancestor, but is unlikely to be protective. We therefore tested the hypothesis that cold nociception functions to protect larvae by triggering cold acclimation. We found that Drosophilamelanogaster Class III nociceptors are sensitized by and critical to cold acclimation and that cold acclimation can be optogenetically evoked, sans cold. Collectively, these findings demonstrate that cold nociception constitutes a peripheral neural basis for Drosophila larval cold acclimation. Drosophila larvae respond to cold via behaviors which are not obviously protective Genetically silencing cold nociceptors results in an inability to cold acclimate Cold acclimation results in nociceptor hypersensitization Cold tolerance can be improved by activating cold nociceptors sans cold Biological sciences; Physiology; Neuroscience; Behavioral neuroscience; Cellular neuroscience; Sensory neuroscience
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影响因子：
2.8
作者：
Gerber, Lucie;Overgaard, Johannes
通讯作者：
Overgaard, Johannes
影响因子：
2.9
作者：
Gilbert, Caroline;Robertson, Graham;Ancel, Andre
通讯作者：
Ancel, Andre
影响因子：
--
作者：
Canals, M;Rosenmann, M;Bozinovic, F
通讯作者：
Bozinovic, F
影响因子：
9.2
作者：
Crook, Robyn J.;Dickson, Katharine;Walters, Edgar T.
通讯作者：
Walters, Edgar T.
DOI：
10.1086/physzool.65.4.30158537
发表时间：
1992-07-01
期刊：
PHYSIOLOGICAL ZOOLOGY
影响因子：
--
作者：
HAYES, JP;SPEAKMAN, JR;RACEY, PA
通讯作者：
RACEY, PA