Kinetic diversity of dopamine transmission in the dorsal striatum.
Kinetic diversity of dopamine transmission in the dorsal striatum.
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DOI：
10.1111/jnc.13059
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发表时间：
2015-05
影响因子：
4.7
通讯作者：
Michael AC
中科院分区：
文献类型：
--
作者：
Taylor IM;Nesbitt KM;Walters SH;Varner EL;Shu Z;Bartlow KM;Jaquins-Gerstl AS;Michael AC
多巴胺 (DA) 是哺乳动物中枢神经系统中一种非常重要的神经递质，在多个时间尺度上发挥作用，影响多种生理功能。 DA 在人类健康中的重要性因其在多种病理中的作用而更加突出。电诱发多巴胺释放的伏安测量揭示了大鼠背侧纹状体中 DA 动力学域拼凑的存在。因此，有必要考虑这些域如何与 DA 功能的特定方面相关。快域和慢域中引起的反应在幅度和时间分布上都是不同的。在此，我们报告快速域中引发的反应可以进一步分为四种不同的类型，即类型 1-4。因此，背侧纹状体总共表现出至少五种不同的诱发反应（4 种快速类型和 1 种慢速类型）。所有五种反应类型均符合完全基于一级速率表达式的动力学模型，这表明反应类型之间的异质性源于背侧纹状体终场内的动力学多样性。我们还报告了背侧纹状体功能不同的子区域以选择性方式表达 DA 动力学多样性。因此，本研究记录了五种反应类型，为每种反应类型提供了彻底的动力学解释，并证实了它们与这个关键 DA 末端区域功能不同的子区域的差异关联。
Dopamine (DA), a highly significant neurotransmitter in the mammalian central nervous system, operates on multiple time scales to affect a diverse array of physiological functions. The significance of DA in human health is heightened by its role in a variety of pathologies. Voltammetric measurements of electrically evoked dopamine release have brought to light the existence of a patchwork of DA kinetic domains in the dorsal striatum of the rat. Thus, it becomes necessary to consider how these domains might be related to specific aspects of DA's functions. Responses evoked in the fast and slow domains are distinct in both amplitude and temporal profile. Herein we report that responses evoked in fast domains can be further classified into four distinct types, types 1-4. The dorsal striatum, therefore, exhibits a total of at least five distinct evoked responses (4 fast types and 1 slow type). All five response types conform to kinetic models based entirely on first order rate expressions, which indicates that the heterogeneity among the response types arises from kinetic diversity within the dorsal striatum terminal field. We report also that functionally distinct sub-regions of the dorsal striatum express DA kinetic diversity in a selective manner. Thus, this study documents five response types, provides a thorough kinetic explanation for each of them, and confirms their differential association with functionally distinct sub-regions of this key DA terminal field.
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