Long non-coding RNA ANRIL is upregulated in hepatocellular carcinoma and regulates cell proliferation by epigenetic silencing of KLF2.
Long non-coding RNA ANRIL is upregulated in hepatocellular carcinoma and regulates cell proliferation by epigenetic silencing of KLF2.
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长的非编码RNA Anril在肝细胞癌中上调，并通过KLF2的表观遗传沉默来调节细胞增殖。
DOI：
10.1186/s13045-015-0153-1
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发表时间：
2015-05-29
影响因子：
28.5
通讯作者：
Shu YQ
中科院分区：
文献类型：
--
作者：
Huang MD;Chen WM;Qi FZ;Xia R;Sun M;Xu TP;Yin L;Zhang EB;De W;Shu YQ
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death, especially in China. And the mechanism of its progression remains poorly understood. Growing evidence indicates that long non-coding RNAs (lncRNAs) are found to be dysregulated in many cancers, including HCC. CDKN2B antisense RNA1 (ANRIL), a lncRNA, coclustered mainly with p14/ARF has been reported to be dysregulated in gastric cancer, esophageal squamous cell carcinoma, and lung cancer. However, its clinical significance and potential role in HCC is still not documented. In this study, expression of ANRIL was analyzed in 77 HCC tissues and matched normal tissues by using quantitative real-time polymerase chain reaction (qRT-PCR). ANRIL expression was up-regulated in HCC tissues, and the higher expression of ANRIL was significantly correlated with tumor size and Barcelona Clinic Liver Cancer (BCLC) stage. Moreover, taking advantage of loss of function experiments in HCC cells, we found that knockdown of ANRIL expression could impair cell proliferation and invasion and induce cell apoptosis both in vitro and in vivo. We also found that ANRIL could epigenetically repress KLF2 transcription in HCC cells by binding with PRC2 and recruiting it to KLF2 promoter region. We also found that Sp1 could regulate the expression of ANRIL. Our results suggest that lncRNA ANRIL, as a growth regulator, may serve as a new biomarker and target for therapy in HCC. The online version of this article (doi:10.1186/s13045-015-0153-1) contains supplementary material, which is available to authorized users.
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影响因子：
64.8
作者：
通讯作者：
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BRAF激活的非编码RNA的下调与非小细胞肺癌的不良预后相关，并通过影响上皮间质转化促进转移
影响因子：
37.3
作者：
Sun M;Liu XH;Wang KM;Nie FQ;Kong R;Yang JS;Xia R;Xu TP;Jin FY;Liu ZJ;Chen JF;Zhang EB;De W;Wang ZX
通讯作者：
Wang ZX
长非编码 RNA ANRIL 通过沉默 KLF2 和 P21 表达促进非小细胞肺癌细胞增殖并抑制细胞凋亡。
影响因子：
5.7
作者：
Nie, Feng-qi;Sun, Ming;Shu, Yong-qian
通讯作者：
Shu, Yong-qian
RNA在意外的地方：长的非编码RNA在不同的细胞环境中起作用。
DOI：
10.1038/nrm3679
发表时间：
2013-11
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Geisler S;Coller J
通讯作者：
Coller J
影响因子：
12.3
作者：
Kaczynski J;Cook T;Urrutia R
通讯作者：
Urrutia R