Echocardiographic 60-day mortality markers in patients hospitalized in intensive care for COVID-19.
Echocardiographic 60-day mortality markers in patients hospitalized in intensive care for COVID-19.
复制标题
DOI：
10.1016/j.hrtlng.2021.12.007
复制
发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Fernández JJD
中科院分区：
文献类型：
--
作者：
Díaz JJS;Rincon JM;López MAR;Zuleta MB;Castellanos N;Saavedra ZS;Rodríguez HC;Barrera DFH;Parra JE;Fernández JJD
冠状病毒疾病COVID-19主要产生肺部病变，心脏受累是多器官功能障碍的重要组成部分。目前，很少有报道的行为，超声心动图图像的患者谁有严重的形式的疾病。确定超声心动图预测重症监护住院患者60天内死亡的标志物。我们对2020年5月至10月期间通过聚合酶链反应确诊的COVID-19重症监护住院患者进行了一项单中心前瞻性队列研究。绘制考克斯多变量模型，报告临床和超声心动图变量的HR和置信区间及其各自的p值。在纳入的326例患者中，153例患者在入院后平均6.8天进行了超声心动图检查。平均年龄为60.7岁，47例患者（30.7%）为女性，67例（44.7%）登记为肌钙蛋白阳性。死亡91例（59.5%）。单变量分析确定TAPSE、LVEF、肺动脉收缩压、急性肺心病、右心室舒张功能障碍和右心室扩张为与死亡率相关的变量。多因素回归模型显示，HR= 4.05（CI 95% 1.09 - 15.02，p 0.037），右心室扩张，HR= 3.33（CI 95% 1.29 - 8.61，p 0.013）和LVEF HR= 0.94（CI 95% 0.89 - 0.99，p 0.020）与60天内死亡率相关。在因COVID-19而在重症监护室住院的患者中，LVEF、急性肺心病和右心室扩张是与60天内死亡相关的预后超声心动图标志物。
Coronavirus disease COVID-19 produces a predominantly pulmonary affection, being cardiac involvement an important component of the multiorganic dysfunction. At the moment there are few reports about the behavior of echocardiographic images in the patients who have the severe forms of the disease. Identify the echocardiographic prognostic markers for death within 60 days in patients hospitalized in intensive care. A single-center prospective cohort was made with patients hospitalized in intensive care for COVID-19 confirmed via polymerase chain reaction who got an echocardiogram between May and October 2020. A Cox multivariate model was plotted reporting the HR and confidence intervals with their respective p values for clinical and echocardiographic variables. Out of the 326 patients included, 153 patients got an echocardiogram performed on average 6.8 days after admission. The average age was 60.7, 47 patients (30.7%) were females and 67 (44.7%) registered positive troponin. 91 patients (59.5%) died. The univariate analysis identified TAPSE, LVEF, pulmonary artery systolic pressure, acute cor pulmonale, right ventricle diastolic dysfunction, and right ventricular dilatation as variables associated with mortality. The multivariate model identified that the acute cor pulmonale with HR= 4.05 (CI 95% 1.09 - 15.02, p 0.037), the right ventricular dilatation with HR= 3.33 (CI 95% 1.29 - 8.61, p 0.013), and LVEF with HR= 0.94 (CI 95% 0.89 - 0.99, p 0.020) were associated with mortality within 60 days. In patients hospitalized in the intensive care unit for COVID-19, the LVEF, acute cor pulmonale and right ventricular dilatation are prognostic echocardiographic markers associated with death within 60 days.
登录
查看更多内容
影响因子：
7.1
作者：
Bagate F;Masi P;d'Humières T;Al-Assaad L;Chakra LA;Razazi K;de Prost N;Carteaux G;Derumeaux G;Mekontso Dessap A
通讯作者：
Mekontso Dessap A
DOI：
10.1177/1179546820977196
发表时间：
2020
期刊：
Clinical Medicine Insights. Cardiology
影响因子：
--
作者：
Thakkar S;Arora S;Kumar A;Jaswaney R;Faisaluddin M;Ammad Ud Din M;Shariff M;Barssoum K;Patel HP;Nirav A;Jani C;Patel K;Savani S;DeSimone C;Mulpuru S;Deshmukh A
通讯作者：
Deshmukh A
DOI：
10.1186/s13054-020-03385-5
发表时间：
2020-11-30
期刊：
Critical care (London, England)
影响因子：
--
作者：
D'Alto M;Marra AM;Severino S;Salzano A;Romeo E;De Rosa R;Stagnaro FM;Pagnano G;Verde R;Murino P;Farro A;Ciccarelli G;Vargas M;Fiorentino G;Servillo G;Gentile I;Corcione A;Cittadini A;Naeije R;Golino P
通讯作者：
Golino P
影响因子：
6.2
作者：
Lang, Roberto M.;Badano, Luigi P.;Voigt, Jens-Uwe
通讯作者：
Voigt, Jens-Uwe
DOI：
10.1016/j.ijantimicag.2020.106024
发表时间：
2020-08-01
影响因子：
10.8
作者：
Lai, Chih-Cheng;Ko, Wen-Chien;Hsueh, Po-Ren
通讯作者：
Hsueh, Po-Ren