Psychological and biological mechanisms linking trauma with cardiovascular disease risk.
Psychological and biological mechanisms linking trauma with cardiovascular disease risk.
复制标题
DOI：
10.1038/s41398-023-02330-8
复制
发表时间：
2023-01-27
影响因子：
6.8
通讯作者：
Gradus, Jaimie L.
中科院分区：
文献类型：
--
作者：
Sumner, Jennifer A.;Cleveland, Shiloh;Chen, Tiffany;Gradus, Jaimie L.
心血管疾病（CVD）是世界范围内导致死亡和残疾的主要原因，心理创伤经历与随后的CVD发病有关。确定创伤与CVD之间的关键通路有可能为更有针对性的筛查和干预工作提供信息，以抵消心血管风险升高。在这篇叙述性综述中，我们总结了创伤经历与心血管疾病风险相关的关键心理和生物学机制的证据。此外，我们描述了测量这些机制的各种方法，以努力为未来与潜在途径相关的研究提供信息。关于创伤后精神病理的机制，绝大多数关于创伤后心理困扰和心血管疾病的研究都集中在创伤后应激障碍（PTSD）上，尽管创伤后精神病理也可以以其他方式表现出来。大量证据表明，创伤后应激障碍预示着创伤暴露的男性和女性一系列心血管疾病的发生，但需要更多的研究来更全面地了解创伤后精神病理学及其与心血管疾病的关系。此外，许多生物系统的失调可能在创伤后和创伤后精神病理中发生；这些免疫系统失调和炎症升高、氧化应激、线粒体功能障碍、肾素-血管紧张素系统失调和加速的生物衰老过程都可能导致随后的心血管风险，尽管需要在创伤应激背景下对这些途径进行更多的研究。鉴于许多这些机制是紧密交织在一起的，未来使用系统生物学方法的研究可能会证明在阐明创伤后如何展开过程有助于心血管疾病。
Cardiovascular disease (CVD) is the leading cause of death and disability worldwide, and experiences of psychological trauma have been associated with subsequent CVD onset. Identifying key pathways connecting trauma with CVD has the potential to inform more targeted screening and intervention efforts to offset elevated cardiovascular risk. In this narrative review, we summarize the evidence for key psychological and biological mechanisms linking experiences of trauma with CVD risk. Additionally, we describe various methodologies for measuring these mechanisms in an effort to inform future research related to potential pathways. With regard to mechanisms involving posttraumatic psychopathology, the vast majority of research on psychological distress after trauma and CVD has focused on posttraumatic stress disorder (PTSD), even though posttraumatic psychopathology can manifest in other ways as well. Substantial evidence suggests that PTSD predicts the onset of a range of cardiovascular outcomes in trauma-exposed men and women, yet more research is needed to better understand posttraumatic psychopathology more comprehensively and how it may relate to CVD. Further, dysregulation of numerous biological systems may occur after trauma and in the presence of posttraumatic psychopathology; these processes of immune system dysregulation and elevated inflammation, oxidative stress, mitochondrial dysfunction, renin-angiotensin system dysregulation, and accelerated biological aging may all contribute to subsequent cardiovascular risk, although more research on these pathways in the context of traumatic stress is needed. Given that many of these mechanisms are closely intertwined, future research using a systems biology approach may prove fruitful for elucidating how processes unfold to contribute to CVD after trauma.
登录
查看更多内容
DOI：
10.1016/j.mrfmmm.2011.04.003
发表时间：
2012-02-01
影响因子：
2.3
作者：
Aubert, Geraldine;Hills, Mark;Lansdorp, Peter M.
通讯作者：
Lansdorp, Peter M.
影响因子：
5.9
作者：
Edmonds, Grant W.;Hampson, Sarah E.;Cote, Helene C. F.;Hill, Patrick L.;Klest, Bridget
通讯作者：
Klest, Bridget
影响因子：
158.5
作者：
ALDERMAN, MH;MADHAVAN, S;LARAGH, JH
通讯作者：
LARAGH, JH
影响因子：
3.7
作者：
Aschbacher, Kirstin;O'Donovan, Aoife;Wolkowitz, Owen M.;Dhabhar, Firdaus S.;Su, Yali;Epel, Elissa
通讯作者：
Epel, Elissa
影响因子：
11
作者：
Baumeister D;Akhtar R;Ciufolini S;Pariante CM;Mondelli V
通讯作者：
Mondelli V