Childhood Personality, Betrayal Trauma, and Leukocyte Telomere Length in Adulthood: A Lifespan Perspective on Conscientiousness and Betrayal Traumas as Predictors of a Biomarker of Cellular Aging.
Childhood Personality, Betrayal Trauma, and Leukocyte Telomere Length in Adulthood: A Lifespan Perspective on Conscientiousness and Betrayal Traumas as Predictors of a Biomarker of Cellular Aging.
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DOI：
10.1002/per.2051
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发表时间：
2016-09
影响因子：
5.9
通讯作者：
Klest, Bridget
中科院分区：
文献类型：
--
作者：
Edmonds, Grant W.;Hampson, Sarah E.;Cote, Helene C. F.;Hill, Patrick L.;Klest, Bridget
关键词：
责任心与长寿有关。因此，确定人格与死亡率之间的生物学途径是重要的。这项研究采用了跨越40年的纵向数据来测试与白细胞端粒长度（LTL）的前瞻性关联，LTL是细胞衰老的潜在标志物。由于端粒随着时间的推移而缩短，并且对氧化应激敏感，因此较短的LTL可能反映了与负面健康行为和过去的压力事件相关的累积损伤。我们调查了儿童时期的焦虑作为一个保护因素，预计与成年后更长的LTL相关，可能反映了LTL缩短较慢。探讨了儿童期创伤、吸烟行为和体重指数（BMI）等潜在的寿命途径。儿童期肥胖表现出与LTL的小的原始关联（r = 0.08，p = 0.04），尽管当控制年龄和性别时，这种影响并不持续。尽管对LTL缺乏直接影响，但我们检测到BMI和吸烟共同产生的间接影响。较高的儿童背叛创伤率与较短的LTL相关。与我们的假设相反，我们发现了与童年背叛创伤相互作用的证据，其中童年背叛创伤与LTL之间的关联对于那些在童年时期表现出更高的忠诚度的人来说更大。
Conscientiousness is associated with longevity. As such, identifying the biological pathways linking personality to mortality is important. This study employs longitudinal data spanning >40 years to test prospective associations with Leukocyte Telomere Length (LTL), a potential marker of cellular aging. Because telomeres shorten over time, and are sensitive to oxidative stress, shorter LTL may reflect cumulative damage associated with negative health behaviors and past stressful events. We investigated childhood conscientiousness as a protective factor, expecting an association with longer LTL in adulthood, possibly reflecting slower LTL shortening. Potential lifespan pathways involving childhood trauma, smoking behaviors, and Body Mass Index (BMI) were explored. Childhood conscientiousness showed a small raw association with LTL (r = .08, p = .04), although this effect did not persist when controlling for age and sex. Despite this lack of a direct effect on LTL, we detected an indirect effect operating jointly through BMI and smoking. Higher rates of childhood betrayal trauma were associated with shorter LTL. Contrary to our hypothesis that conscientiousness would buffer this effect, we found evidence for an interaction with childhood betrayal traumas where the association between childhood betrayal traumas and LTL was larger for those higher on conscientiousness in childhood.
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影响因子：
3.7
作者：
Der G;Batty GD;Benzeval M;Deary IJ;Green MJ;McGlynn L;McIntyre A;Robertson T;Shiels PG
通讯作者：
Shiels PG
影响因子：
3.7
作者：
Edmonds GW;Côté HC;Hampson SE
通讯作者：
Hampson SE
影响因子：
14.9
作者：
Cawthon RM
通讯作者：
Cawthon RM
健康，衰老和身体成分研究中的教育程度和末期端粒长度。
影响因子：
15.1
作者：
Adler, Nancy;Pantell, Matthew S.;O'Donovan, Aoife;Blackburn, Elizabeth;Cawthon, Richard;Koster, Annemarie;Opresko, Patricia;Newman, Anne;Harris, Tamara B.;Epel, Elissa
通讯作者：
Epel, Elissa
影响因子：
3.3
作者：
Edmonds GW;Goldberg LR;Hampson SE;Barckley M
通讯作者：
Barckley M