What is the dynamical regime of cerebral cortex?
What is the dynamical regime of cerebral cortex?
复制标题
大脑皮层的动态状态是什么？
DOI：
10.1016/j.neuron.2021.07.031
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发表时间：
2021-11-03
期刊：
影响因子：
16.2
通讯作者：
Miller, Kenneth D.
中科院分区：
文献类型：
--
作者：
Ahmadian, Yashar;Miller, Kenneth D.
许多研究表明，大脑皮层神经元接受的兴奋和抑制在许多情况下大致保持平衡。理解大脑皮层动态机制的一个关键问题是这种平衡的性质。理论家已经证明，网络动力学可以通过抑制产生系统地消除神经元的大部分兴奋性输入。我们回顾了一系列证据，指出这种抵消发生在平衡松散的制度下，这意味着在取消激发和抑制之后剩余的净投入在大小上与取消的因素相当，而不是紧的，这意味着净投入相对于抵消因素非常小。这种机制的选择对皮质功能反应具有重要的影响，正如我们所描述的：松散平衡，但不是紧平衡，可以产生在感觉皮质神经元中看到的许多非线性群体行为，允许相关变异性的存在，并随着外部刺激驱动的增加而减少这种变异性，正如在多个皮质区域观察到的那样。
Many studies have shown that the excitation and inhibition received by cortical neurons remain roughly balanced across many conditions. A key question for understanding the dynamical regime of cortex is the nature of this balancing. Theorists have shown that network dynamics can yield systematic cancellation of most of a neuron’s excitatory input by inhibition. We review a wide range of evidence pointing to this cancellation occurring in a regime in which the balance is loose, meaning that the net input remaining after cancellation of excitation and inhibition is comparable in size to the factors that cancel, rather than tight, meaning that the net input is very small relative to the cancelling factors. This choice of regime has important implications for cortical functional responses, as we describe: loose balance, but not tight balance, can yield many nonlinear population behaviors seen in sensory cortical neurons, allow the presence of correlated variability, and yield decrease of that variability with increasing external stimulus drive as observed across multiple cortical areas.
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影响因子：
2.5
作者：
Cavanaugh, JR;Bair, W;Movshon, JA
通讯作者：
Movshon, JA
树突状GABA能抑制的输入特异性NMDAR依赖性增强。
影响因子：
16.2
作者：
Chiu CQ;Martenson JS;Yamazaki M;Natsume R;Sakimura K;Tomita S;Tavalin SJ;Higley MJ
通讯作者：
Higley MJ
视觉皮层回路中兴奋-抑制平衡的每日振荡
影响因子：
16.2
作者：
Bridi, Michelle C. D.;Zong, Fang-Jiao;Min, Xia;Luo, Nancy;Tran, Trinh;Qiu, Jiaqian;Severin, Daniel;Zhang, Xue-Ting;Wang, Guanglin;Zhu, Zheng-Jiang;He, Kai-Wen;Kirkwood, Alfredo
通讯作者：
Kirkwood, Alfredo
DOI：
10.1523/jneurosci.2581-12.2012
发表时间：
2012-10-03
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Amatrudo JM;Weaver CM;Crimins JL;Hof PR;Rosene DL;Luebke JI
通讯作者：
Luebke JI
影响因子：
3.2
作者：
Lankarany M;Heiss JE;Lampl I;Toyoizumi T
通讯作者：
Toyoizumi T