Daily Oscillation of the Excitation-Inhibition Balance in Visual Cortical Circuits.
Daily Oscillation of the Excitation-Inhibition Balance in Visual Cortical Circuits.
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视觉皮层回路中兴奋-抑制平衡的每日振荡
DOI：
10.1016/j.neuron.2019.11.011
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发表时间：
2020-02-19
期刊：
影响因子：
16.2
通讯作者：
Kirkwood, Alfredo
中科院分区：
文献类型：
--
作者：
Bridi, Michelle C. D.;Zong, Fang-Jiao;Min, Xia;Luo, Nancy;Tran, Trinh;Qiu, Jiaqian;Severin, Daniel;Zhang, Xue-Ting;Wang, Guanglin;Zhu, Zheng-Jiang;He, Kai-Wen;Kirkwood, Alfredo
在一个狭窄的窗口内维持突触兴奋和抑制之间的动态平衡(E/I平衡)被广泛认为是皮层处理的关键。根据这一想法，据报道，E/I平衡的测量方法在邻近神经元、跨行为状态和发育阶段之间是相似的，在自闭症和精神分裂症的小鼠模型中也发生了变化。在这些想法的激励下，我们检查了突触抑制是否在24小时内发生变化，以补偿已有文献证明的突触兴奋的睡眠依赖变化。我们发现，在视觉和前额叶皮质的锥体细胞以及在海马CA1区，突触抑制的强度也在24小时的光/暗周期中发生变化，但令人惊讶的是，突触兴奋的方向与之相反。在光相期间，视皮层抑制的上调依赖于睡眠。值得注意的是，在视觉皮层，E/I平衡的这些变化是在反馈回路中观察到的，而不是前馈回路。E/I平衡不是恒定的，而是在一天的过程中振荡，并且只在特定的电路中振荡，这一观察结果对E/I平衡的功能和调节提出了新的有趣的问题。
A dynamic balance between synaptic excitation and inhibition (E/I balance) maintained within a narrow window is widely regarded to be crucial for cortical processing. In line with this idea, measures of the E/I balance are reportedly comparable across neighboring neurons, across behavioral states and developmental stages, and altered in mouse models of autism and schizophrenia. Motivated by these ideas, we examined whether synaptic inhibition changes over the 24-hour day to compensate for the well-documented sleep-dependent changes in synaptic excitation. We found that in pyramidal cells of visual and prefrontal cortices as well as in hippocampal CA1, the strength of synaptic inhibition also changes over the 24h light/dark cycle, but surprisingly, in the opposite direction of synaptic excitation. The upregulation of inhibition in visual cortex during the light phase is sleep-dependent. Notably, in visual cortex, these changes in the E/I balance were observed in feedback, but not feedforward, circuits. The observations that the E/I balance is not constant but oscillates over the course of the day, and only in specific circuits, opens new and interesting questions on the function and regulation of the E/I balance.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
4.6
作者：
Chellappa SL;Gaggioni G;Ly JQ;Papachilleos S;Borsu C;Brzozowski A;Rosanova M;Sarasso S;Luxen A;Middleton B;Archer SN;Dijk DJ;Massimini M;Maquet P;Phillips C;Moran RJ;Vandewalle G
通讯作者：
Vandewalle G
DOI：
10.1126/science.1166673
发表时间：
2009-04-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gilestro GF;Tononi G;Cirelli C
通讯作者：
Cirelli C
影响因子：
25
作者：
Busche, Marc Aurel;Kekus, Maja;Konnerth, Arthur
通讯作者：
Konnerth, Arthur
影响因子：
2.5
作者：
Fortin, DA;Trettel, J;Levine, ES
通讯作者：
Levine, ES