Immune regulation through mitochondrion-dependent dendritic cell death induced by T regulatory cells.
Immune regulation through mitochondrion-dependent dendritic cell death induced by T regulatory cells.
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DOI：
10.4049/jimmunol.1101834
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发表时间：
2011-12-01
期刊：
影响因子：
--
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Chen M;Felix K;Wang J
Dendritic cells (DCs) harbor an active mitochondrion-dependent cell death pathway regulated by Bcl-2 family members and undergo rapid turnover in vivo. However, the functions for mitochondrion-dependent cell death of DCs in immune regulation remain to be elucidated. Here we show that DC-specific knockout of pro-apoptotic Bcl-2 family members, Bax and Bak, induced spontaneous T cell activation and autoimmunity in mice. In addition to a defect in spontaneous cell death, Bax−/−Bak−/− DCs were resistant to killing by CD4+FoxP3+ T regulatory (Treg) cells compared to wild type DCs. Treg cells inhibited the activation of T effector cells by wild type, but not Bax−/−Bak−/− DCs. Bax−/−Bak−/− DCs showed increased propensity for inducing autoantibodies. Moreover, the autoimmune potential of Bax−/−Bak−/− DCs was resistant to suppression by Treg cells. Our data suggest that Bax and Bak not only mediate intrinsic spontaneous cell death in DCs, but also regulate DC killing triggered by Treg cells. Bax- and Bak-dependent cell death mechanisms help to maintain DC homeostasis, and contribute to the regulation of T cell activation and the suppression of autoimmunity.
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影响因子：
32.4
作者：
Fontenot, JD;Rasmussen, JP;Rudensky, AY
通讯作者：
Rudensky, AY
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DOI：
10.4049/jimmunol.0800459
发表时间：
2009-04-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
Wang, J
影响因子：
32.4
作者：
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通讯作者：
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