Analysis of the Aerosol Generated from Tetrahydrocannabinol, Vitamin E Acetate, and Their Mixtures.
Analysis of the Aerosol Generated from Tetrahydrocannabinol, Vitamin E Acetate, and Their Mixtures.
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DOI：
10.3390/toxics10020088
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发表时间：
2022-02-15
期刊：
影响因子：
4.6
通讯作者：
Ivanov A
中科院分区：
文献类型：
--
作者：
Mikheev VB;Ivanov A
电子烟或电子烟产品使用相关的肺损伤（EVALI）爆发与维生素E醋酸酯（VEA）用作四氢大麻酚（THC）的溶剂有关。进行了几项研究，以评估VEA（和THC/VEA混合物）热降解的产物，作为从传统类型（线圈-棉芯）和陶瓷类型线圈蒸汽笔蒸发/雾化的结果。VEA气溶胶的粒度分布（PSD）以及VEA和THC/VEA混合物被加热到的温度也针对几种类型的传统和陶瓷蒸汽笔进行测量。本研究评估了在两种不同的温度设置和两种抽吸流速下使用dab型vape笔从THC、VEA和许多THC/VEA混合物产生的气溶胶的PSD。还评估了THC、VEA和THC/VEA混合物的热降解，并测量了盘管温度。结果表明，PSD依赖于雾化混合物的化学含量，以及对膨化流量。观察到最低限度的热降解。检测到了电子烟笔设计中的缺陷，这些缺陷很可能会影响结果。讨论了VEA、THC和THC/VEA混合物与某些类型的电子烟笔的适用性。
E-cigarette, or vaping, product use–associated lung injury (EVALI) outbreak was linked to vitamin E acetate (VEA) used as a solvent for tetrahydrocannabinol (THC). Several studies were conducted to assess the products of VEA (and THC/VEA mixtures) thermal degradation as a result of vaporizing/aerosolizing from a traditional type (coil—cotton wick) and ceramic type coil vape pens. The particle size distribution (PSD) of VEA aerosol and the temperature VEA and THC/VEA mixtures are heated to were also measured for a few types of traditional and ceramic vape pens. The current study assessed the PSD of the aerosol generated from THC, VEA, and a number of THC/VEA mixtures using a dab-type vape pen under two different temperature settings and two puffing flow rates. Thermal degradation of THC, VEA, and THC/VEA mixtures were also assessed, and coil temperature was measured. Results showed the dependence of the PSD upon the chemical content of the aerosolized mixture as well as upon the puffing flow rate. Minimal thermal degradation was observed. Flaws in the vape pen’s design, which most likely affected results, were detected. The suitability of VEA, THC, and THC/VEA mixtures with certain types of vape pens was discussed.
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影响因子：
5.5
作者：
Puetz A;Morel Espinosa M;Watson C;Blount BC;Valentín-Blasini L
通讯作者：
Valentín-Blasini L
影响因子：
2.7
作者：
Lovestead, Tara M.;Bruno, Thomas J.
通讯作者：
Bruno, Thomas J.
DOI：
10.1164/rccm.201912-2332ws
发表时间：
2020-09-15
影响因子：
24.7
作者：
Alexander, Laura E. Crotty;Ware, Lorraine B.;Tarran, Robert
通讯作者：
Tarran, Robert
影响因子：
5.2
作者：
Mikheev, Vladimir B.;Ivanov, Alexander;Clark, Pamela I.
通讯作者：
Clark, Pamela I.
影响因子：
5.8
作者：
Schripp, T.;Markewitz, D.;Salthammer, T.
通讯作者：
Salthammer, T.