Antibiotic-chemoattractants enhance neutrophil clearance of Staphylococcus aureus.
Antibiotic-chemoattractants enhance neutrophil clearance of Staphylococcus aureus.
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抗生素化学引诱剂增强中性粒细胞对金黄色葡萄球菌的清除。
DOI：
10.1038/s41467-021-26244-5
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发表时间：
2021-10-25
影响因子：
16.6
通讯作者：
Cryle MJ
中科院分区：
文献类型：
--
作者：
Payne JAE;Tailhades J;Ellett F;Kostoulias X;Fulcher AJ;Fu T;Leung R;Louch S;Tran A;Weber SA;Schittenhelm RB;Lieschke GJ;Qin CH;Irima D;Peleg AY;Cryle MJ
The pathogen Staphylococcus aureus can readily develop antibiotic resistance and evade the human immune system, which is associated with reduced levels of neutrophil recruitment. Here, we present a class of antibacterial peptides with potential to act both as antibiotics and as neutrophil chemoattractants. The compounds, which we term ‘antibiotic-chemoattractants’, consist of a formylated peptide (known to act as chemoattractant for neutrophil recruitment) that is covalently linked to the antibiotic vancomycin (known to bind to the bacterial cell wall). We use a combination of in vitro assays, cellular assays, infection-on-a-chip and in vivo mouse models to show that the compounds improve the recruitment, engulfment and killing of S. aureus by neutrophils. Furthermore, optimizing the formyl peptide sequence can enhance neutrophil activity through differential activation of formyl peptide receptors. Thus, we propose antibiotic-chemoattractants as an alternate approach for antibiotic development. Antibiotic resistance in Staphylococcus aureus is associated with reduced neutrophil recruitment. Here, Payne et al. link formylated peptides, which act as chemoattractants for neutrophils, with the antibiotic vancomycin and show that these hybrid compounds improve clearance of S. aureus by neutrophils.
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DOI：
10.1016/j.bbadis.2007.06.001
发表时间：
2007-09
影响因子：
6.2
作者：
Mills, John S.
通讯作者：
Mills, John S.
影响因子：
3.2
作者：
Gripentrog, Jeannie M.;Mills, John S.;Saari, George J.;Miettinen, Heini M.
通讯作者：
Miettinen, Heini M.
影响因子：
16.6
作者：
Blaskovich MAT;Hansford KA;Gong Y;Butler MS;Muldoon C;Huang JX;Ramu S;Silva AB;Cheng M;Kavanagh AM;Ziora Z;Premraj R;Lindahl F;Bradford TA;Lee JC;Karoli T;Pelingon R;Edwards DJ;Amado M;Elliott AG;Phetsang W;Daud NH;Deecke JE;Sidjabat HE;Ramaologa S;Zuegg J;Betley JR;Beevers APG;Smith RAG;Roberts JA;Paterson DL;Cooper MA
通讯作者：
Cooper MA
影响因子：
6.1
作者：
Ellett, Felix;Jalali, Fatemeh;Irimia, Daniel
通讯作者：
Irimia, Daniel
影响因子：
3.6
作者：
Becker, EL;Forouhar, FA;Murphy, PM
通讯作者：
Murphy, PM