Ketogenic diet alleviates cognitive dysfunction and neuroinflammation in APP/PS1 mice via the Nrf2/HO-1 and NF-κB signaling pathways.
Ketogenic diet alleviates cognitive dysfunction and neuroinflammation in APP/PS1 mice via the Nrf2/HO-1 and NF-κB signaling pathways.
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生酮饮食通过Nrf2/HO-1和NF-κB信号通路缓解APP/PS1小鼠认知功能障碍和神经炎症。
DOI：
10.4103/1673-5374.373715
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发表时间：
2023-12
影响因子：
6.1
通讯作者：
Chen S
中科院分区：
文献类型：
--
作者：
Jiang J;Pan H;Shen F;Tan Y;Chen S
阿尔茨海默病是一种进行性神经系统疾病，其特征是认知能力下降和大脑内的慢性炎症。生酮饮食是一种被广泛认可的治疗难治性癫痫的干预措施，最近被提出作为一种潜在的治疗各种神经系统疾病，包括阿尔茨海默病。然而，生酮饮食治疗阿尔茨海默病的疗效及其潜在机制仍不清楚。本研究旨在探讨生酮饮食对阿尔茨海默病小鼠模型认知功能的影响及其生物学机制。将雄性淀粉样前体蛋白/早老素1（APP/PS1）小鼠随机分配到生酮饮食组或对照饮食组，并接受各自的饮食持续3个月。研究结果表明，生酮饮食管理增强了APP/PS1小鼠的认知功能，减弱了淀粉样斑块形成和促炎细胞因子水平，并增强了核因子-红细胞2-p45衍生因子2/血红素加氧酶-1信号通路，同时抑制了核因子-κ B通路。总的来说，这些数据表明生酮饮食可能通过改善与Aβ诱导的炎症相关的神经毒性而具有治疗阿尔茨海默病的治疗潜力。这项研究强调了迫切需要进一步研究生酮饮食作为阿尔茨海默病的潜在治疗方法。
Alzheimer’s disease is a progressive neurological disorder characterized by cognitive decline and chronic inflammation within the brain. The ketogenic diet, a widely recognized therapeutic intervention for refractory epilepsy, has recently been proposed as a potential treatment for a variety of neurological diseases, including Alzheimer’s disease. However, the efficacy of ketogenic diet in treating Alzheimer’s disease and the underlying mechanism remains unclear. The current investigation aimed to explore the effect of ketogenic diet on cognitive function and the underlying biological mechanisms in a mouse model of Alzheimer’s disease. Male amyloid precursor protein/presenilin 1 (APP/PS1) mice were randomly assigned to either a ketogenic diet or control diet group, and received their respective diets for a duration of 3 months. The findings show that ketogenic diet administration enhanced cognitive function, attenuated amyloid plaque formation and proinflammatory cytokine levels in APP/PS1 mice, and augmented the nuclear factor-erythroid 2-p45 derived factor 2/heme oxygenase-1 signaling pathway while suppressing the nuclear factor-kappa B pathway. Collectively, these data suggest that ketogenic diet may have a therapeutic potential in treating Alzheimer’s disease by ameliorating the neurotoxicity associated with Aβ-induced inflammation. This study highlights the urgent need for further research into the use of ketogenic diet as a potential therapy for Alzheimer’s disease.
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影响因子：
168.9
作者：
Ballard, Clive;Gauthier, Serge;Jones, Emma
通讯作者：
Jones, Emma
影响因子：
4.9
作者：
通讯作者：
--
影响因子：
6.1
作者：
Bajwa, Ekta;Klegeris, Andis
通讯作者：
Klegeris, Andis
影响因子：
14.8
作者：
Leger, Marianne;Quiedeville, Anne;Freret, Thomas
通讯作者：
Freret, Thomas
DOI：
10.1007/978-1-4939-8994-2_10
发表时间：
2019-01-01
期刊：
PRE-CLINICAL MODELS
影响因子：
--
作者：
Kraeuter, Ann-Katrin;Guest, Paul C.;Sarnyai, Zoltan
通讯作者：
Sarnyai, Zoltan