Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust.
Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust.
复制标题
DOI：
10.1016/j.trsl.2015.01.001
复制
发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Romberger DJ
中科院分区：
文献类型：
--
作者：
Nordgren TM;Bauer CD;Heires AJ;Poole JA;Wyatt TA;West WW;Romberger DJ
Agriculture industry workers are at a higher risk for chronic bronchitis and obstructive pulmonary diseases, and current therapeutics are not entirely effective. We previously found that the specialized pro-resolving lipid mediator (SPM) maresin-1 (MaR1) reduced pro-inflammatory cytokine release and intracellular adhesion molecule-1 (ICAM-1) expression in bronchial epithelial cells exposed to extracts of organic dust (DE) derived from swine confinement facilities in vitro. The objective of this study was to determine whether MaR1 is effective at limiting lung inflammation associated with acute and repetitive exposures to DE in an established murine model of inhalant dust exposures. C57Bl/6 mice were treated with MaR1 or vehicle control and intranasally instilled with DE once or daily for 3 weeks. Bronchial alveolar lavage fluid was analyzed for total and differential cell counts and pro-inflammatory cytokine levels, and lung tissues were assessed for histopathology and ICAM-1 expression. In both single and repetitive DE exposure studies, MaR1 significantly decreased bronchoalveolar lavage neutrophil infiltration, IL-6, TNF-α, and CXCL1 levels without altering repetitive DE-induced bronchiolar/alveolar inflammation or lymphoid aggregate formation. Lung tissue ICAM-1 expression was also reduced in both single and repetitive exposure studies. These data suggest that MaR1 might contribute to an effective strategy to reduce airway inflammatory diseases induced by agricultural-related organic dust environmental exposures.
登录
查看更多内容
影响因子：
3.7
作者：
Hsiao HM;Sapinoro RE;Thatcher TH;Croasdell A;Levy EP;Fulton RA;Olsen KC;Pollock SJ;Serhan CN;Phipps RP;Sime PJ
通讯作者：
Sime PJ
影响因子：
5.8
作者：
Nordgren TM;Heires AJ;Wyatt TA;Poole JA;LeVan TD;Cerutis DR;Romberger DJ
通讯作者：
Romberger DJ
影响因子：
15.9
作者：
Ji RR;Xu ZZ;Strichartz G;Serhan CN
通讯作者：
Serhan CN
影响因子：
6.3
作者：
Palmberg, L;Larssson, BM;Larsson, K
通讯作者：
Larsson, K
影响因子：
4.4
作者：
Marcon, Rodrigo;Bento, Allisson F.;Calixto, Joao B.
通讯作者：
Calixto, Joao B.