Decreased infectivity following BNT162b2 vaccination: A prospective cohort study in Israel.
Decreased infectivity following BNT162b2 vaccination: A prospective cohort study in Israel.
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DOI：
10.1016/j.lanepe.2021.100150
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Kreiss Y
中科院分区：
文献类型：
--
作者：
Regev-Yochay G;Amit S;Bergwerk M;Lipsitch M;Leshem E;Kahn R;Lustig Y;Cohen C;Doolman R;Ziv A;Novikov I;Rubin C;Gimpelevich I;Huppert A;Rahav G;Afek A;Kreiss Y
BNT162b2预防COVID-19的有效率为92%。优先推广疫苗和实现群体免疫取决于减少SARS-CoV-2传播。因此，疫苗对传染性的影响是一个关键的优先事项。在以色列一家大型三级医疗中心的所有9650名HCW中，我们计算了无症状表现的SARS-CoV-2 qRT-PCR阳性病例的患病率，在已知或推定暴露后进行了检测，并计算了这些病例的感染亚群（n基因- ct值<30）。此外，计算有症状病例和感染性（Ct<30）病例的感染发生率。疫苗推出后三个月内的疫苗有效性分别以1减去相对危险率或比率来衡量。为了进一步评估传染性，我们比较了接种疫苗和未接种疫苗的平均ct值和SARS-CoV-2抗原检测阳性的感染比例。检测前一周IgG水平与Ct水平的相关性。在充分接种HCW疫苗的人群中，观察到(i)由于暴露而检测到感染，无症状表现（VE(i)=65.1%, 95%CI 45-79%）， （ii）推定感染（Ct<30）亚群（VE(ii)=69.6%, 95%CI 43-84%）， （iii）无症状感染（VE(iii)=72.3%, 95%CI 48-86%），以及（iv）推定感染（VE(iv)=83.0%, 95%CI 51-94%）。完全接种疫苗的个体与未接种疫苗的个体相比，(v)症状性和（vi）症状性感染病例的发生率显著降低(VE（v)= 89.7%, 95%CI 84-94%， VE(vi)=88.1%, 95%CI 80-95%）。接种疫苗的平均ct值显著高于未接种疫苗的（27.3±1.2比22.2±1.0,p<0.001）， pcr阳性HCW疫苗接种者的SARS-CoV-2抗原检测阳性比例也显著低于未接种疫苗的（80%比31%，p<0.001）。IgG浓度越高，传染性越低（R=0.36, p=0.01）。这些结果表明，BNT162b2通过预防感染和减少病毒脱落，具有中等到高度的降低传染性的作用。示巴医疗中心，以色列
BNT162b2 was shown to be 92% effective in preventing COVID-19. Prioritizing vaccine rollout, and achievement of herd immunity depend on SARS-CoV-2 transmission reduction. The vaccine's effect on infectivity is thus a critical priority. Among all 9650 HCW of a large tertiary medical center in Israel, we calculated the prevalence of positive SARS-CoV-2 qRT-PCR cases with asymptomatic presentation, tested following known or presumed exposure and the infectious subset (N-gene-Ct-value<30) of these. Additionally, infection incidence rates were calculated for symptomatic cases and infectious (Ct<30) cases. Vaccine effectiveness within three months of vaccine rollout was measured as one minus the relative risk or rate ratio, respectively. To further assess infectiousness, we compared the mean Ct-value and the proportion of infections with a positive SARS-CoV-2 antigen test of vaccinated vs. unvaccinated. The correlation between IgG levels within the week before detection and Ct level was assessed. Reduced prevalence among fully vaccinated HCW was observed for (i) infections detected due to exposure, with asymptomatic presentation (VE(i)=65.1%, 95%CI 45-79%), (ii) the presumed infectious (Ct<30) subset of these (VE(ii)=69.6%, 95%CI 43-84%) (iii) never-symptomatic infections (VE(iii)=72.3%, 95%CI 48-86%), and (iv) the presumed infectious (Ct<30) subset (VE(iv)=83.0%, 95%CI 51-94%). Incidence of (v) symptomatic and (vi) symptomatic-infectious cases was significantly lower among fully vaccinated vs. unvaccinated individuals (VE(v)= 89.7%, 95%CI 84-94%, VE(vi)=88.1%, 95%CI 80-95%). The mean Ct-value was significantly higher in vaccinated vs. unvaccinated (27.3±1.2 vs. 22.2±1.0, p<0.001) and the proportion of positive SARS-CoV-2 antigen tests was also significantly lower among vaccinated vs. unvaccinated PCR-positive HCW (80% vs. 31%, p<0.001). Lower infectivity was correlated with higher IgG concentrations (R=0.36, p=0.01). These results suggest that BNT162b2 is moderately to highly effective in reducing infectivity, via preventing infection and through reducing viral shedding. Sheba Medical Center, Israel
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影响因子：
82.9
作者：
Levine-Tiefenbrun, Matan;Yelin, Idan;Kishony, Roy
通讯作者：
Kishony, Roy
影响因子：
19
作者：
Singanayagam, Anika;Patel, Monika;Gopal, Robin
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Gopal, Robin
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DOI：
10.1056/nejmoa2034577
发表时间：
2020-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Polack FP;Thomas SJ;Kitchin N;Absalon J;Gurtman A;Lockhart S;Perez JL;Pérez Marc G;Moreira ED;Zerbini C;Bailey R;Swanson KA;Roychoudhury S;Koury K;Li P;Kalina WV;Cooper D;Frenck RW Jr;Hammitt LL;Türeci Ö;Nell H;Schaefer A;Ünal S;Tresnan DB;Mather S;Dormitzer PR;Şahin U;Jansen KU;Gruber WC;C4591001 Clinical Trial Group
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C4591001 Clinical Trial Group
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影响因子：
15.1
作者：
Oved K;Olmer L;Shemer-Avni Y;Wolf T;Supino-Rosin L;Prajgrod G;Shenhar Y;Payorsky I;Cohen Y;Kohn Y;Indenbaum V;Lazar R;Geylis V;Oikawa MT;Shinar E;Stoyanov E;Keinan-Boker L;Bassal R;Reicher S;Yishai R;Bar-Chaim A;Doolman R;Reiter Y;Mendelson E;Livneh Z;Freedman LS;Lustig Y
通讯作者：
Lustig Y
DOI：
10.1093/cid/ciaa1616
发表时间：
2021-08-16
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Gniazdowski V;Paul Morris C;Wohl S;Mehoke T;Ramakrishnan S;Thielen P;Powell H;Smith B;Armstrong DT;Herrera M;Reifsnyder C;Sevdali M;Carroll KC;Pekosz A;Mostafa HH
通讯作者：
Mostafa HH