Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila.
Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila.
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DOI：
10.1038/s41467-021-20898-x
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发表时间：
2021-01-27
影响因子：
16.6
通讯作者：
Hirano Y
中科院分区：
文献类型：
--
作者：
Takakura M;Nakagawa R;Ota T;Kimura Y;Ng MY;Alia AG;Okuno H;Hirano Y
合并内存可以根据环境变化而保留或更新。尽管在内存更新过程中可能会发生这种相互冲突的调节，但内存更新的灵活性可能在初始内存整合过程中就已经确定了。在这里，我们探讨了记忆巩固中活动依赖性转录的门控机制，这是出乎意料地与果蝇的后期记忆更新。通过蛋白质组学分析，我们发现，在转录阻遏物，其中包含组蛋白去乙酰化酶Rpd 3和CorRest的组成变化，作为门控机制，打开和关闭的时间窗口的活性依赖性转录。通过Rpd 3/CorRest中的组成变化打开门对于内存整合是必需的，但是通过Rpd 3/CorRest关闭门对于限制未来的内存更新是重要的。我们的数据表明，记忆更新的灵活性是通过最初的活动依赖性转录决定的，提供了一个机制，参与定义记忆状态。存储器更新的灵活性可以在初始存储器合并过程中确定。在这里，作者展示了转录抑制复合物的蛋白质组变化，这些蛋白质组变化是最初记忆巩固所必需的，并影响未来记忆更新的灵活性。
Consolidated memory can be preserved or updated depending on the environmental change. Although such conflicting regulation may happen during memory updating, the flexibility of memory updating may have already been determined in the initial memory consolidation process. Here, we explored the gating mechanism for activity-dependent transcription in memory consolidation, which is unexpectedly linked to the later memory updating in Drosophila. Through proteomic analysis, we discovered that the compositional change in the transcriptional repressor, which contains the histone deacetylase Rpd3 and CoRest, acts as the gating mechanism that opens and closes the time window for activity-dependent transcription. Opening the gate through the compositional change in Rpd3/CoRest is required for memory consolidation, but closing the gate through Rpd3/CoRest is significant to limit future memory updating. Our data indicate that the flexibility of memory updating is determined through the initial activity-dependent transcription, providing a mechanism involved in defining memory state. The flexibility of memory updating may be determined in the initial memory consolidation process. Here, the authors show the proteomic changes of the transcriptional repressor complexes required for initial memory consolidation and influencing the flexibility of future memory updating.
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影响因子：
7.7
作者：
Aso Y;Hattori D;Yu Y;Johnston RM;Iyer NA;Ngo TT;Dionne H;Abbott LF;Axel R;Tanimoto H;Rubin GM
通讯作者：
Rubin GM
DOI：
10.1093/bioinformatics/btu638
发表时间：
2015-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Anders S;Pyl PT;Huber W
通讯作者：
Huber W
影响因子：
7.2
作者：
Alberini, Cristina M.;Kandel, Eric R.
通讯作者：
Kandel, Eric R.
影响因子：
64.5
作者：
BOURTCHULADZE, R;FRENGUELLI, B;SILVA, AJ
通讯作者：
SILVA, AJ
影响因子：
64.8
作者：
DASH, PK;HOCHNER, B;KANDEL, ER
通讯作者：
KANDEL, ER