Perceptual, cognitive, and personality rigidity in Parkinson's disease.
Perceptual, cognitive, and personality rigidity in Parkinson's disease.
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DOI：
10.1016/j.neuropsychologia.2015.01.044
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发表时间：
2015-03
期刊：
影响因子：
2.6
通讯作者：
Cronin-Golomb, Alice
中科院分区：
文献类型：
--
作者：
Diaz-Santos, Mirella;Cao, Bo;Yazdanbakhsh, Arash;Norton, Daniel J.;Neargarder, Sandy;Cronin-Golomb, Alice
关键词：
帕金森病（PD）与运动和非运动强直症状（例如，认知和个性）。提出的问题是刚性PD是否也延伸到知觉，如果是这样，是否知觉，认知和人格的刚性相关。双稳态刺激，提出了28个非痴呆的个人与PD和26个正常对照成年人（NC）。内克尔立方体知觉和双眼竞争进行了检查，在被动观看，和内克尔立方体另外用于两个意志控制条件：持有一个知觉在前面，并在两个知觉之间切换。相对于被动观看，PD明显低于NC，以减少优势持续时间在开关条件下，表明知觉刚性。认知灵活性和人格问卷的测试进行了管理，以探讨与知觉僵化的关联。两组的认知灵活性与知觉僵化无关。人格（新奇寻求）与显性持续时间内克尔被动观看PD，但不NC。结果表明，存在轻度中度PD的知觉刚性，并建议共享的神经基板与新奇的寻求，但功能的分歧，从那些支持认知灵活性。提出的可能性，知觉僵化可能是一个预兆的认知能力，后来在疾病的过程。
Parkinson’s disease (PD) is associated with motor and non-motor rigidity symptoms (e.g., cognitive and personality). The question is raised as to whether rigidity in PD also extends to perception, and if so, whether perceptual, cognitive, and personality rigidities are correlated. Bistable stimuli were presented to 28 non-demented individuals with PD and 26 normal control adults (NC). Necker cube perception and binocular rivalry were examined during passive viewing, and the Necker cube was additionally used for two volitional-control conditions: Hold one percept in front, and Switch between the two percepts. Relative to passive viewing, PD were significantly less able than NC to reduce dominance durations in the Switch condition, indicating perceptual rigidity. Tests of cognitive flexibility and a personality questionnaire were administered to explore the association with perceptual rigidity. Cognitive flexibility was not correlated with perceptual rigidity for either group. Personality (novelty seeking) correlated with dominance durations on Necker passive viewing for PD but not NC. The results indicate the presence in mild-moderate PD of perceptual rigidity and suggest shared neural substrates with novelty seeking, but functional divergence from those supporting cognitive flexibility. The possibility is raised that perceptual rigidity may be a harbinger of cognitive inflexibility later in the disease course.
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DOI：
10.4061/2011/908306
发表时间：
2011
期刊：
Parkinson's disease
影响因子：
--
作者：
Armstrong RA
通讯作者：
Armstrong RA
影响因子：
5.3
作者：
Fraessle, Stefan;Sommer, Jens;Einhaeuser, Wolfgang
通讯作者：
Einhaeuser, Wolfgang
影响因子：
1.9
作者：
BLAKE, R;OSHEA, RP;MUELLER, TJ
通讯作者：
MUELLER, TJ
影响因子：
1.8
作者：
Kang, Min-Suk
通讯作者：
Kang, Min-Suk
影响因子：
3.4
作者：
Beck, AT;Steer, RA;Ranieri, WF
通讯作者：
Ranieri, WF