The limit of tolerable micromotion for implant osseointegration: a systematic review.
The limit of tolerable micromotion for implant osseointegration: a systematic review.
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DOI：
10.1038/s41598-021-90142-5
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发表时间：
2021-05-24
影响因子：
4.6
通讯作者：
van Arkel RJ
中科院分区：
文献类型：
--
作者：
Kohli N;Stoddart JC;van Arkel RJ
大量的研究工作正在投入到多孔生物材料的发展，提高种植体骨整合。骨-种植体界面的大的微动会损害这种骨整合过程，导致纤维囊形成和种植体松动。本系统性综述汇编了所有可用的体内证据，以确定种植体骨整合的可容忍微动是否存在普遍限制。该方案已在国际系统性综述前瞻性登记系统（ID：CRD 42020196686）中注册。检索Pubmed、Scopus和Web of Knowledge数据库中包含微动和骨整合相关术语的研究。骨结合种植体的微动平均值是非骨结合种植体微动平均值的32%（112 ± 176 µm vs 349 ± 231 µm，p < 0.001）。然而，数据范围有很大的重叠，没有明显的普遍限制。相反，发现许多因素联合收割机影响整体结果，包括加载时间、植入物类型和所用材料。本综述中提供的表格总结了这些因素，并将帮助研究者确定与其生物材料和植入物开发研究最相关的微动值。
Much research effort is being invested into the development of porous biomaterials that enhance implant osseointegration. Large micromotions at the bone-implant interface impair this osseointegration process, resulting in fibrous capsule formation and implant loosening. This systematic review compiled all the in vivo evidence available to establish if there is a universal limit of tolerable micromotion for implant osseointegration. The protocol was registered with the International Prospective Register for Systematic Reviews (ID: CRD42020196686). Pubmed, Scopus and Web of Knowledge databases were searched for studies containing terms relating to micromotion and osseointegration. The mean value of micromotion for implants that osseointegrated was 32% of the mean value for those that did not (112 ± 176 µm versus 349 ± 231 µm, p < 0.001). However, there was a large overlap in the data ranges with no universal limit apparent. Rather, many factors were found to combine to affect the overall outcome including loading time, the type of implant and the material being used. The tables provided in this review summarise these factors and will aid investigators in identifying the most relevant micromotion values for their biomaterial and implant development research.
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DOI：
10.1002/jab.770060303
发表时间：
1995-09-01
期刊：
JOURNAL OF APPLIED BIOMATERIALS
影响因子：
--
作者：
GOODMAN, S;ASPENBERG, P;LIDGREN, L
通讯作者：
LIDGREN, L
影响因子：
3.5
作者：
Bragdon, CR;Burke, D;Harris, WH
通讯作者：
Harris, WH
影响因子：
2.4
作者：
Claes, LE;Heigele, CA
通讯作者：
Heigele, CA
影响因子：
3.7
作者：
Jorgensen, Peter Bo;Daugaard, Henrik;Stilling, Maiken
通讯作者：
Stilling, Maiken
影响因子：
2.8
作者：
Barnes, Spencer C.;Clasper, Jon C.;Jeffers, Jonathan R. T.
通讯作者：
Jeffers, Jonathan R. T.