In vivo photothermal optical coherence tomography of endogenous and exogenous contrast agents in the eye.
In vivo photothermal optical coherence tomography of endogenous and exogenous contrast agents in the eye.
复制标题
内源性和外源性对比剂的体内光热光学相干断层扫描。
DOI：
10.1038/s41598-017-10050-5
复制
发表时间：
2017-08-23
影响因子：
4.6
通讯作者：
Skala MC
中科院分区：
文献类型：
--
作者：
Lapierre-Landry M;Gordon AY;Penn JS;Skala MC
Optical coherence tomography (OCT) has become a standard-of-care in retinal imaging. OCT allows non-invasive imaging of the tissue structure but lacks specificity to contrast agents that could be used for in vivo molecular imaging. Photothermal OCT (PT-OCT) is a functional OCT-based technique that has been developed to detect absorbers in a sample. We demonstrate in vivo PT-OCT in the eye for the first time on both endogenous (melanin) and exogenous (gold nanorods) absorbers. Pigmented mice and albino mice (n = 6 eyes) were used to isolate the photothermal signal from the melanin in the retina. Pigmented mice with laser-induced choroidal neovascularization lesions (n = 7 eyes) were also imaged after a systemic injection of gold nanorods to observe their passive accumulation in the retina. This experiment demonstrates the feasibility of PT-OCT to image the distribution of both endogenous and exogenous absorbers in the mouse retina.
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.0913679107
发表时间：
2010-05-04
影响因子：
11.1
作者：
John, Renu;Rezaeipoor, Robabeh;Boppart, Stephen A.
通讯作者：
Boppart, Stephen A.