Development of luminal protein digestion: implications for biologically active dietary polypeptides.
Development of luminal protein digestion: implications for biologically active dietary polypeptides.
复制标题
管腔蛋白质消化的发展：对生物活性膳食多肽的影响。
DOI：
10.1097/00005176-198908000-00004
复制
发表时间：
1989
影响因子：
2.9
通讯作者：
Koldovsky,O
中科院分区：
文献类型：
--
作者：
Britton,JR;Koldovsky,O
在几个物种的乳汁中已经检测到许多潜在的生物活性肽和蛋白质。这些包括激素，生长因子，抗感染蛋白，过敏原和酶（1-8）。在许多情况下，这些肽在牛奶中的浓度很高，相应的发育迟缓，在相关的消化过程中的年轻的动物提出了可能性，牛奶的因素可能会弥补明显的新生儿限制。实例包括分泌型免疫球蛋白A（伊加）和人乳脂肪酶，其可分别在新生哺乳动物中提供粘膜免疫和脂质水解，其中已观察到相对低的内源性分泌型免疫球蛋白和胰脂肪酶产生（2，9）。可以想象，乳肽可以在发育中的胃肠道内发挥作用，或者被吸收并在远处的身体部位发挥作用。任一现象的先决条件是肽以其完整形式或作为活性加工消化产物的胃肠腔存活。活性肽的存活又取决于肽对消化的固有敏感性与发育中哺乳动物中负责蛋白质降解的机制之间的平衡。由于后者在围产期发生变化，这种平衡也在发生变化。胃肠病学家和生理学家通常认为管腔蛋白质消化的过程是“完全的”，因为它通常导致氨基酸和小肽的形成，从而使其可用于ab-。
A number of potentially biologically active peptides and proteins have been detected in the milk of several species. These include hormones, growth factors, antiinfectious proteins, allergins, and enzymes (1–8). In many cases, these peptides are present in high concentrations in milk, and corresponding developmental delays in related digestive processes in the young animal have suggested the possibility that milk factors might compensate for apparent neonatal limitations. Examples include secretory immunoglobulin A (IgA) and human milk lipase, which may provide for mucosal immunity and lipid hydrolysis in the newborn mammal, respectively, in which relatively low endogenous secretory immunoglobulin and pancreatic lipase production have been observed (2, 9). Conceivably, milk peptides could function within the developing gastrointestinal tract or be absorbed and exert actions at distant body sites. A prerequisite for either phenomenon is gastrointestinal luminal survival of the peptide in either its intact form or as an active processed digestion product. Survival of an active peptide in turn depends upon a balance between the intrinsic susceptibility of the peptide to digestion and the mechanisms responsible for protein degradation in the developing mammal. Since the latter undergo changes during the perinatal period, this balance is also changing. The process of luminal protein digestion is generally considered by gastroenterologists and physiologists to be “complete” in that it usually results in the formation of amino acids and small peptides that are consequently rendered available for ab-
登录
查看更多内容
影响因子：
3.9
作者：
ARMBRECHT, HJ;WASSERMAN, RH;BRUNS, MEH
通讯作者：
BRUNS, MEH
通过磷酸盐消耗刺激 25-羟基维生素 D3-1α-羟化酶。
影响因子：
4.8
作者：
L. A. Baxter;H. DeLuca
通讯作者：
H. DeLuca
膳食钙和磷对给予维生素 D 代谢物的大鼠肠道钙转运的影响。
影响因子：
3.9
作者：
M. Ribovich;H. F. DeLuca
通讯作者：
H. F. DeLuca
大鼠肠道中氧依赖性 1,25-二羟基胆钙化醇诱导的钙离子转运。
DOI：
10.1042/bj1940178
发表时间：
1981
期刊：
The Biochemical journal
影响因子：
--
作者：
Kendrick,NC;Kabakoff,B;DeLuca,HF
通讯作者：
DeLuca,HF
屏障饲养 Fischer 344 雄性大鼠衰老过程中的病理变化1
DOI：
--
发表时间：
1977
期刊：
Journal of Gerontology
影响因子：
--
作者：
G. L. Coleman;S. Barthold;G. Osbaldiston;Sumner J. Foster;A. M. Jonas
通讯作者：
A. M. Jonas