The in vitro estrogenic activities of polyfluorinated iodine alkanes.
The in vitro estrogenic activities of polyfluorinated iodine alkanes.
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多氟碘烷的体外雌激素活性
DOI：
10.1289/ehp.1103773
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发表时间：
2012-01
影响因子：
10.4
通讯作者：
Jiang G
中科院分区：
文献类型：
--
作者：
Wang C;Wang T;Liu W;Ruan T;Zhou Q;Liu J;Zhang A;Zhao B;Jiang G
背景：多氟碘烷烃（PFIs）是合成有机氟化物产品的重要中间体。最近，在作为残留原材料的含氟聚合物以及周围环境中检测到PFI。目的：全氟辛烷磺酸的高产量和潜在的环境排放可能成为一个问题，但这些化学品的接触风险和毒性仍不清楚。在这项研究中，我们研究了PFIs的潜在雌激素效应。研究方法：我们研究了氟化碘烷（FIA），氟化调聚物碘化物（FTIs），氟化二碘烷（FDIA）的雌激素效应，使用E-screen和MVLN测定和评价MCF-7细胞中的雌激素反应基因。结果：FIA在全氟碳链的一端具有碘原子。1-全氟碘己烷（PFHxI）和全氟碘辛烷（PFOI）可促进MCF-7细胞增殖，诱导MVLN细胞荧光素酶活性，上调TFF1和EGR3的表达。在这些试验中，其他FIA均呈阴性反应。FDIA在全氟碳链的每一端都有一个碘原子，所有FDIA都显示出雌激素效应。FIA和FDIA的雌激素效力与化学品的碳链长度密切相关。雌激素效应的最佳链长是六个碳，然后是八个和四个碳。所有FTI在部分氟化碳链的末端具有单个碘原子。在测试中，没有一种FTIs显示出雌激素效应。结论：PFIs的雌激素样作用依赖于碘取代的结构特征和链长。本研究将有助于进一步了解全氟化合物的雌激素效应。
Background: Polyfluorinated iodine alkanes (PFIs) are important intermediates in the synthesis of organic fluoride products. Recently, PFIs have been detected in fluoropolymers as residual raw materials, as well as in the ambient environment. Objectives: High production volumes and potential environmental releases of PFIs might become a concern, but the exposure risk and toxicity of these chemicals are still unclear. In this study, we investigated the potential estrogenic effects of PFIs. Methods: We studied the estrogenic effects of fluorinated iodine alkanes (FIAs), fluorinated telomer iodides (FTIs), and fluorinated diiodine alkanes (FDIAs) using the E-screen and MVLN assays and the evaluation of estrogen-responsive genes in MCF-7 cells. Results: FIAs have an iodine atom at one end of the perfluorinated carbon chain. 1-Iodoperfluorohexane (PFHxI) and 1-iodoperfluorooctane (PFOI) promoted the proliferation of MCF-7 cells, induced luciferase activity in MVLN cells, and up-regulated the expression of TFF1 and EGR3. In these assays, other FIAs gave negative responses. FDIAs have an iodine atom at each end of the perfluorinated carbon chain, and all the FDIAs showed estrogenic effects. The estrogenic potencies of FIAs and FDIAs correlate well with the carbon chain length of the chemicals. The optimum chain length for estrogenic effects is six carbons, and then eight and four carbons. All FTIs have a single iodine atom at the end of a partially fluorinated carbon chain. None of the FTIs showed estrogenic effects in the tests. Conclusions: The estrogenic effects of PFIs are dependent on the structural features of iodine substitution and chain length. This research will be helpful in further understanding the estrogenic effects of perfluorinated compounds.
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影响因子：
10.4
作者：
BERGERON, JM;CREWS, D;MCLACHLAN, JA
通讯作者：
MCLACHLAN, JA
影响因子：
3.8
作者：
Blair, RM;Fang, H;Sheehan, DM
通讯作者：
Sheehan, DM
影响因子：
10.4
作者：
Jorgensen, M;Vendelbo, B;Leffers, H
通讯作者：
Leffers, H
影响因子：
11.4
作者：
Ellis, DA;Martin, JW;Wallington, TJ
通讯作者：
Wallington, TJ
全氟化合物引起的突触传递、钙电流和神经突生长的变化取决于链长和官能团。
影响因子：
11.4
作者：
Liao, Chunyang;Wang, Thanh;Jiang, Guibin
通讯作者：
Jiang, Guibin