Validation of thoracic quantitative computed tomography as a method to measure bone mineral density.
Validation of thoracic quantitative computed tomography as a method to measure bone mineral density.
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验证胸部定量计算机断层扫描作为测量骨矿物质密度的方法。
DOI：
10.1007/s00223-004-0020-5
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发表时间：
2005
影响因子：
4.2
通讯作者：
Detrano,R
中科院分区：
文献类型：
--
作者：
Wong,M;Papa,A;Lang,T;Hodis,HN;Labree,L;Detrano,R
低骨量是艾滋病毒感染者的常见症状。在接受抗逆转录病毒治疗的垂直感染儿童中发现骨量减少。对于未经抗逆转录病毒治疗的水平感染年轻患者的骨量知之甚少。我们使用双能X线吸收法（DXA）测量了16名未经抗逆转录病毒治疗的HIV感染儿童（年龄9.3 ± 3.9岁）和119名健康儿童（年龄9.7 ± 3.3岁）的腰椎和整个骨骼的骨矿物质含量（BMC）。13例患者还通过人体测量、性别和年龄与健康儿童配对。HIV感染儿童脊柱BMC中位数为14.9 g（8.2 - 39.2 g），全身BMC中位数为1106.1 g（55.5 - 2344.1 g）。健康儿童脊柱骨矿物质含量为18.6 g（6.8-52.2 g），全身骨矿物质含量为1213.5 g（541.0-2722.0 g）。多因素分析显示两组间脊柱BMC值的平均差异为0.004 g（P = 0.64）。同样，两组之间的全身BMC差异（0.001 g）无统计学显著性（P = 0.55）。病例对照评价中的平均脊柱BMC测量值为21.1 g（9.7 g）（患者）和22.3 g（6.9 g）（对照）。患者和对照组的全身BMC测量值分别为1258.5 g（539.6 g）和1311.1 g（479.2 g）。在这两种情况下，差异并不显著。HIV感染的持续时间与BMC值无关。总之，未经抗逆转录病毒治疗的水平HIV感染儿童的骨矿物质测量结果与健康儿童相当。
Low bone mass is a frequent finding in HIV-infected individuals. Reduced bone mass has been found in vertically infected children who are receiving antiretroviral treatment. Little is known about bone mass in horizontally infected young patients who are naïve to antiretroviral therapy. We measured the bone mineral content (BMC) at the lumbar spine and in the whole skeleton by using dual-energy X-ray absorptiometry (DXA) in 16 HIV-infected children (age 9.3 ± 3.9 years) naïve to antiretroviral treatment, and in 119 healthy children (age 9.7 ± 3.3 years). Thirteen patients were also pair-matched by anthropometric measures, sex, and age with healthy children. Median spine BMC of HIV-infected children was 14.9 g (8.2–39.2 g), and whole body BMC was 1106.1 g (55.5–2344.1 g). Spine BMC of healthy children was 18.6 g (6.8–52.2 g), and whole body BMC was 1213.5 g (541.0–2722.0 g). Multivariate analysis showed a mean difference of spine BMC values of 0.004 g (P= 0.64) between the two groups. Similarly, the whole body BMC difference between the two groups (0.001 g) was not statistically significant (P= 0.55). Mean spine BMC measurements in the case-control evaluation were 21.1 g (9.7 g) (patients), and 22.3 g (6.9 g) (controls). Whole body BMC measurements of patients and controls were 1258.5 g (539.6 g) and 1311.1 g (479.2 g), respectively. In both cases the differences were not significant. The duration of HIV infection did not relate to BMC values. In conclusion, horizontally HIV-infected children naïve to antiretroviral therapy have bone mineral measurements comparable to those of healthy children.
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DOI：
10.1016/s0022-3476(87)80336-0
发表时间：
1987
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Weinberg,GA;Einhorn,MS;Lenoir,AA;Granoff,PD;Granoff,DM
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Granoff,DM
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DOI：
10.1093/infdis/153.3.448
发表时间：
1986
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Granoff,DM;MunsonJr,RS
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MunsonJr,RS
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影响因子：
5
作者：
J. Gilsdorf
通讯作者：
J. Gilsdorf
b 型流感嗜血杆菌分离株外膜蛋白 P2 的纯化和比较。
DOI：
10.1172/jci111017
发表时间：
1983
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
MunsonJr,RS;Shenep,JL;Barenkamp,SJ;Granoff,DM
通讯作者：
Granoff,DM
b型流感嗜血杆菌分离株外膜蛋白亚型和生物型的比较。
DOI：
10.1093/infdis/144.5.480
发表时间：
1981
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Barenkamp,SJ;MunsonJr,RS;Granoff,DM
通讯作者：
Granoff,DM