Intravesical Contrast-Enhanced MRI: A Potential Tool for Bladder Cancer Surveillance and Staging.
Intravesical Contrast-Enhanced MRI: A Potential Tool for Bladder Cancer Surveillance and Staging.
复制标题
静脉造影剂增强的MRI：膀胱癌监测和分期的潜在工具。
DOI：
10.3390/curroncol30050350
复制
发表时间：
2023-04-30
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
这篇评论文章概述了膀胱癌成像的当前技术水平，然后深入讨论了新型成像方法的科学和技术优点，追踪了其从小鼠癌症模型到癌症患者的演变。虽然广泛使用的成像方法（如腹部超声和放射CT）对软组织的分辨率较差，但它们仅适用于测量大体肿瘤体积和膀胱壁增厚，而动态对比增强磁分辨率成像（DCE MRI）在解决肌肉浸润方面具有明显的上级优势。然而，在其通过方面仍然存在重大障碍。膀胱内对比增强MRI（ICE-MRI）不是注射DCE-MRI，而是滴注钆螯合物（Gadobutrol）以及痕量的超顺磁性剂，用于测量肿瘤体积、深度和侵袭性。ICE-MRI利用泄漏的紧密连接，通过踩荧光素钠和丝裂霉素（<400道尔顿）进入膀胱肿瘤的细胞旁进入途径，加速Gadobutrol（604.71道尔顿）的被动细胞旁扩散。膀胱癌的诊断和护理成本飙升可以通过减少使用昂贵的手术室资源和潜在的非手术成像选项进行癌症监测来缓解，从而减少过度诊断和过度治疗并增加器官保护。
This review article gives an overview of the current state of the art of bladder cancer imaging and then discusses in depth the scientific and technical merit of a novel imaging approach, tracing its evolution from murine cancer models to cancer patients. While the poor resolution of soft tissue obtained by widely available imaging options such as abdominal sonography and radiation-based CT leaves them only suitable for measuring the gross tumor volume and bladder wall thickening, dynamic contrast-enhanced magnetic resolution imaging (DCE MRI) is demonstrably superior in resolving muscle invasion. However, major barriers still exist in its adoption. Instead of injection for DCE-MRI, intravesical contrast-enhanced MRI (ICE-MRI) instills Gadolinium chelate (Gadobutrol) together with trace amounts of superparamagnetic agents for measurement of tumor volume, depth, and aggressiveness. ICE-MRI leverages leaky tight junctions to accelerate passive paracellular diffusion of Gadobutrol (604.71 Daltons) by treading the paracellular ingress pathway of fluorescein sodium and of mitomycin (<400 Daltons) into bladder tumor. The soaring cost of diagnosis and care of bladder cancer could be mitigated by reducing the use of expensive operating room resources with a potential non-surgical imaging option for cancer surveillance, thereby reducing over-diagnosis and over-treatment and increasing organ preservation.
登录
查看更多内容
影响因子：
2.5
作者：
Bansal, Ravi;Hao, Xuejun;Liu, Feng;Xu, Dongrong;Liu, Jun;Peterson, Bradley S.
通讯作者：
Peterson, Bradley S.
影响因子：
2.6
作者：
Finn, J. P.;Nguyen, K. -L.;Han, F.;Zhou, Z.;Salusky, I.;Ayad, I.;Hu, P.
通讯作者：
Hu, P.
影响因子：
17.1
作者：
Davis RM;Kiss B;Trivedi DR;Metzner TJ;Liao JC;Gambhir SS
通讯作者：
Gambhir SS
影响因子：
3.3
作者：
Bellin, Marie-France;Van Der Molen, Aart J.
通讯作者：
Van Der Molen, Aart J.
DOI：
10.1055/s-2000-3751
发表时间：
2000-06-01
影响因子：
1.8
作者：
Beyersdorff, D;Taupitz, M;Hamm, B
通讯作者：
Hamm, B