Pattern recognition receptors and cytokines in Mycobacterium tuberculosis infection--the double-edged sword?
Pattern recognition receptors and cytokines in Mycobacterium tuberculosis infection--the double-edged sword?
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结核分枝杆菌感染中的模式识别受体和细胞因子 - 双刃剑？
DOI：
10.1155/2013/179174
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发表时间：
2013
影响因子：
--
通讯作者：
Norazmi MN
中科院分区：
文献类型：
--
作者：
Hossain MM;Norazmi MN
结核病是一种由结核分枝杆菌（Mycobacterium tuberculosis，Mtb）引起的传染病，目前仍是世界范围内人类死亡的主要原因。先天免疫提供宿主对Mtb的防御。以巨噬细胞和树突状细胞（DCs）识别结核分枝杆菌为特征的吞噬作用是先天免疫防御机制的第一步。Mtb的识别由模式识别受体（PRR）介导，其在先天性免疫细胞上表达，包括Toll样受体（TLR）、补体受体、核苷酸寡聚化结构域样受体、树突状细胞特异性细胞间粘附分子抓取非整合素（DC-SIGN）、甘露糖受体、CD 14受体、清道夫受体和FCγ受体。分枝杆菌配体与PRR的相互作用导致巨噬细胞和DC分泌选定的细胞因子，其进而诱导干扰素-γ-（IFNγ-）主导的免疫。IFNγ和其他细胞因子如肿瘤坏死因子-α（TNFα）调节分枝杆菌生长、肉芽肿形成和对Mtb的适应性免疫应答的启动，并最终为宿主提供保护。然而，Mtb可以逃避先天免疫系统的抗微生物防御机制的破坏，因为系统的一些组分可以促进细菌在这些细胞中的存活并促进发病机制。因此，尽管先天免疫成分通常对Mtb发挥保护作用，但它们也可能促进Mtb的生存。参与选定的PRRs和细胞因子对这些看似矛盾的作用进行了讨论。
Tuberculosis, an infectious disease caused by Mycobacterium tuberculosis (Mtb), remains a major cause of human death worldwide. Innate immunity provides host defense against Mtb. Phagocytosis, characterized by recognition of Mtb by macrophages and dendritic cells (DCs), is the first step of the innate immune defense mechanism. The recognition of Mtb is mediated by pattern recognition receptors (PRRs), expressed on innate immune cells, including toll-like receptors (TLRs), complement receptors, nucleotide oligomerization domain like receptors, dendritic cell-specific intercellular adhesion molecule grabbing nonintegrin (DC-SIGN), mannose receptors, CD14 receptors, scavenger receptors, and FCγ receptors. Interaction of mycobacterial ligands with PRRs leads macrophages and DCs to secrete selected cytokines, which in turn induce interferon-γ- (IFNγ-) dominated immunity. IFNγ and other cytokines like tumor necrosis factor-α (TNFα) regulate mycobacterial growth, granuloma formation, and initiation of the adaptive immune response to Mtb and finally provide protection to the host. However, Mtb can evade destruction by antimicrobial defense mechanisms of the innate immune system as some components of the system may promote survival of the bacteria in these cells and facilitate pathogenesis. Thus, although innate immunity components generally play a protective role against Mtb, they may also facilitate Mtb survival. The involvement of selected PRRs and cytokines on these seemingly contradictory roles is discussed.
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DOI：
10.4049/jimmunol.181.8.5545
发表时间：
2008-10-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Beamer GL;Flaherty DK;Assogba BD;Stromberg P;Gonzalez-Juarrero M;de Waal Malefyt R;Vesosky B;Turner J
通讯作者：
Turner J
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
2.7
作者：
Barreiro, Luis B.;Quach, Helene;Quintana-Murci, Lluis
通讯作者：
Quintana-Murci, Lluis
影响因子：
3.1
作者：
Cehovin, Ana;Coates, Anthony R. M.;Henderson, Brian
通讯作者：
Henderson, Brian
影响因子：
4.8
作者：
Bulut, Y;Michelsen, KS;Arditi, M
通讯作者：
Arditi, M