Associations of thyroid hormone serum levels with in-vivo Alzheimer's disease pathologies.
Associations of thyroid hormone serum levels with in-vivo Alzheimer's disease pathologies.
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DOI：
10.1186/s13195-017-0291-5
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发表时间：
2017-08-17
期刊：
影响因子：
--
通讯作者：
KBASE Research Group
中科院分区：
文献类型：
--
作者：
Choi HJ;Byun MS;Yi D;Sohn BK;Lee JH;Lee JY;Kim YK;Lee DY;KBASE Research Group
本研究探讨了认知正常（CN）中老年人群中，血清甲状腺激素水平或促甲状腺激素（TSH）与阿尔茨海默病（AD）特异性生物标志物脑淀粉样蛋白β (Aβ)负荷和糖代谢之间的关系。本研究评估了148名CN患者，他们接受了全面的临床和神经心理学评估，包括11c -匹兹堡化合物B (PiB)-正电子发射断层扫描（PET）， 18f -脱氧葡萄糖(FDG)-PET扫描，以及血清三碘甲状腺原氨酸（T3），游离T3，游离甲状腺素（fT4）和TSH水平的量化。所有参与者均为临床甲状腺功能正常。在控制了年龄、性别和载脂蛋白Eε4 （APOEε4）基因型的影响后，血清fT4水平与整体脑Aβ沉积呈独立负相关。虽然血清TSH水平与整体大脑a β沉积无关，但在控制年龄、性别和APOEε4基因型后，TSH水平与楔前叶/后扣带皮层的葡萄糖代谢呈显著负相关。没有其他甲状腺激素显示与脑Aβ负荷或葡萄糖代谢有关。即使在临床甲状腺功能正常状态下，低血清fT4和高血清TSH水平似乎与ad特异性脑改变存在差异。本文的在线版本（doi:10.1186/s13195-017-0291-5）包含补充材料，可供授权用户使用。
The present study investigated the relationships between thyroid hormone serum levels or thyroid-stimulating hormone (TSH) and two Alzheimer’s disease (AD)-specific biomarkers, cerebral amyloid beta (Aβ) burden and glucose metabolism, in AD-signature brain regions in cognitively normal (CN) middle-aged and older individuals. This study assessed 148 CN individuals who received comprehensive clinical and neuropsychological assessments that included 11C-Pittsburgh Compound B (PiB)-positron emission tomography (PET) scans, 18F-deoxyglucose (FDG)-PET scans, and the quantification of serum triiodothyronine (T3), free T3, free thyroxine (fT4), and TSH levels. All participants were clinically euthyroid. Independent negative associations were found between serum fT4 levels and global cerebral Aβ deposition after controlling for the effects of age, gender, and the apolipoprotein E ε4 (APOEε4) genotype. Although serum TSH levels were not associated with global cerebral Aβ deposition, they had a significant negative association with glucose metabolism in the precuneus/posterior cingulate cortex after controlling for age, gender, and the APOEε4 genotype. No other thyroid hormones exhibited relationships with either brain Aβ burden or glucose metabolism. Even in a clinical euthyroid state, low serum fT4 and high serum TSH levels appear to be differentially associated with AD-specific brain changes. The online version of this article (doi:10.1186/s13195-017-0291-5) contains supplementary material, which is available to authorized users.
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