Formation of milk lipids: a molecular perspective.

Formation of milk lipids: a molecular perspective.
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DOI:
10.2217/clp.09.15
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发表时间:
2009
影响因子:
--
通讯作者:
McManaman JL
McManaman JL
中科院分区:
其他
文献类型:
--
作者:
McManaman JL

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脂质,主要是甘油三酯,是大多数哺乳动物的主要乳汁成分,提供新生儿生长和发育所需的大百分比的卡路里、必需脂肪酸和生物活性脂质。为了满足新生儿的热量和营养需求,大多数物种的乳腺在哺乳期间已经进化出合成和分泌大量脂质的巨大能力。通过对产奶动物的研究,获得了关于乳腺脂质代谢生理调节的重要信息。然而,通过小鼠遗传学、乳腺基因表达的全球分析、细胞器蛋白质特性和脂质代谢的细胞生物学的进展,对调节乳脂质形成的分子机制的详细了解现在才成为焦点。
Lipids, primarily triglycerides, are major milk constituents of most mammals, providing a large percentage of calories, essential fatty acids and bioactive lipids required for neonatal growth and development. To meet the caloric and nutritional demands of newborns, the mammary glands of most species have evolved an enormous capacity to synthesize and secrete large quantities of lipids during lactation. Significant information exists regarding the physiological regulation of lipid metabolism in the mammary gland from the study of dairy animals. However, detailed understanding of the molecular mechanisms regulating milk lipid formation is only now coming into focus through advances in mouse genetics, global analysis of mammary gland gene expression, organelle protein properties and the cell biology of lipid metabolism.
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