Tick-Tock Consider the Clock: The Influence of Circadian and External Cycles on Time of Day Variation in the Human Metabolome-A Review.
Tick-Tock Consider the Clock: The Influence of Circadian and External Cycles on Time of Day Variation in the Human Metabolome-A Review.
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DOI：
10.3390/metabo11050328
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发表时间：
2021-05-19
期刊：
影响因子：
4.1
通讯作者：
Dunn WB
中科院分区：
文献类型：
--
作者：
Hancox TPM;Skene DJ;Dallmann R;Dunn WB
在过去的十年中，大量工作涌入研究不同人体生物体液和组织代谢组在一天中的时间变化。这种每日变化的驱动因素可能是由中枢和/或外周时钟驱动的内源性昼夜节律，也可能是由行为和环境周期驱动的外源性昼夜节律，表现为代谢物浓度的规律的 24 小时周期。这篇综述对迄今为止所有已发表的研究进行了回顾，确定了在血液、唾液、尿液、呼吸和骨骼肌中观察到的“节律性”代谢物的数量和特性的每日变化程度。除了常见节律代谢物的汇编列表之外，还描述了驱动这种变化的可能来源，以及最容易粘附或脱离这种循环的代谢物类别。审查的研究表明，代谢组在一天中的不同时间发生显着变化，主要观察到氨基酸和多种脂质类别。这种由本文讨论的各种因素驱动的 24 小时节律是个体内/个体间变异的另一个来源，因此与应用非靶向和靶向代谢组学平台的所有研究高度相关，特别是对于生物标志物组的构建。讨论了潜在的影响以及拟议的最低报告标准，建议承认一天中的时间变化是结果的潜在影响，并促进提高可重复性。
The past decade has seen a large influx of work investigating time of day variation in different human biofluid and tissue metabolomes. The driver of this daily variation can be endogenous circadian rhythms driven by the central and/or peripheral clocks, or exogenous diurnal rhythms driven by behavioural and environmental cycles, which manifest as regular 24 h cycles of metabolite concentrations. This review, of all published studies to date, establishes the extent of daily variation with regard to the number and identity of ‘rhythmic’ metabolites observed in blood, saliva, urine, breath, and skeletal muscle. The probable sources driving such variation, in addition to what metabolite classes are most susceptible in adhering to or uncoupling from such cycles is described in addition to a compiled list of common rhythmic metabolites. The reviewed studies show that the metabolome undergoes significant time of day variation, primarily observed for amino acids and multiple lipid classes. Such 24 h rhythms, driven by various factors discussed herein, are an additional source of intra/inter-individual variation and are thus highly pertinent to all studies applying untargeted and targeted metabolomics platforms, particularly for the construction of biomarker panels. The potential implications are discussed alongside proposed minimum reporting criteria suggested to acknowledge time of day variation as a potential influence of results and to facilitate improved reproducibility.
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作者：
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通讯作者：
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影响因子：
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