Characterization of lens based photoacoustic imaging system.
Characterization of lens based photoacoustic imaging system.
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DOI：
10.1016/j.pacs.2017.09.003
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发表时间：
2017-12
期刊：
影响因子：
7.9
通讯作者：
Rao N
中科院分区：
文献类型：
--
作者：
Francis KJ;Chinni B;Channappayya SS;Pachamuthu R;Dogra VS;Rao N
将光声(PA)成像转化为临床应用的一些挑战包括目标组织的有限视野、低信噪比以及开发实时系统的高成本。在这些场景中，基于声透镜的PA成像系统，也称为PA相机，是传统成像系统的潜在替代方案。透镜的3D调焦作用使二维换能器阵列能够实时进行C扫描成像。在本文中，我们在成像系统的数学框架中对PA相机中的基本物理进行建模，并推导出点扩展函数(PSF)的封闭形式表达式。随后进行了实验验证，包括如何以低成本设计和制造透镜的细节。系统PSF是在此PA相机可以成像的3D体积上进行评估的。通过成像体模和体外人前列腺组织样本验证了该方法的有效性。
Some of the challenges in translating photoacoustic (PA) imaging to clinical applications includes limited view of the target tissue, low signal to noise ratio and the high cost of developing real-time systems. Acoustic lens based PA imaging systems, also known as PA cameras are a potential alternative to conventional imaging systems in these scenarios. The 3D focusing action of lens enables real-time C-scan imaging with a 2D transducer array. In this paper, we model the underlying physics in a PA camera in the mathematical framework of an imaging system and derive a closed form expression for the point spread function (PSF). Experimental verification follows including the details on how to design and fabricate the lens inexpensively. The system PSF is evaluated over a 3D volume that can be imaged by this PA camera. Its utility is demonstrated by imaging phantom and an ex vivo human prostate tissue sample.
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