The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment.
The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment.
复制标题
BDNF在严重抑郁症和抗抑郁治疗中的病理生理学中的作用。
DOI：
10.4306/pi.2010.7.4.231
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发表时间：
2010-12
影响因子：
2.7
通讯作者：
Kim YK
中科院分区：
文献类型：
--
作者：
Lee BH;Kim YK
神经营养因子是神经网络形成和可塑性的关键调节因子。脑源性神经营养因子(BDNF)在脑和外周组织中含量丰富，在人血清和血浆中均有发现。动物研究已经证明，压力会降低海马区BDNF的表达或活性，这种减少可以通过抗抑郁药物的治疗来阻止。在患有严重抑郁障碍(MDD)的患者的大脑中，BDNF活性也发生了类似的变化。最近的临床研究表明，未经治疗的MDD患者血清或血浆BDNF水平降低。抗抑郁治疗至少四周可使降低的BDNF功能恢复至正常值。因此，MDD与神经元可塑性受损有关。自杀行为可能是大脑神经元可塑性严重受损的结果。抗抑郁药物治疗可促进BDNF活性的增加以及几种形式的神经元可塑性，包括神经发生、突触形成和神经元成熟。脑源性神经营养因子也可能在神经元网络的调节中发挥重要作用。这种神经元的可塑性变化可以积极影响情绪或恢复抑郁的情绪。MDD患者抗抑郁治疗前后脑源性神经营养因子水平或神经元可塑性的这些变化可以通过检测血清或血浆中脑源性神经营养因子的浓度来衡量。因此，脑源性神经营养因子水平可能是临床反应或抑郁症状改善的有用标记物，但它们不是重度抑郁症的诊断标记物。
Neurotrophic factors are critical regulators of the formation and plasticity of neuronal networks. Brain-derived neurotrophic factor (BDNF) is abundant in the brain and periphery, and is found in both human serum and plasma. Animal studies have demonstrated that stress reduces BDNF expression or activity in the hippocampus and that this reduction can be prevented by treatment with antidepressant drugs. A similar change in BDNF activity occurs in the brain of patients with major depression disorder (MDD). Recently, clinical studies have indicated that serum or plasma BDNF levels are decreased in untreated MDD patients. Antidepressant treatment for at least four weeks can restore the decreased BDNF function up to the normal value. Therefore, MDD is associated with impaired neuronal plasticity. Suicidal behavior can be a consequence of severe impaired neuronal plasticity in the brain. Antidepressant treatment promotes increased BDNF activity as well as several forms of neuronal plasticity, including neurogenesis, synaptogenesis and neuronal maturation. BDNF could also play an important role in the modulation of neuronal networks. Such a neuronal plastic change can positively influence mood or recover depressed mood. These alterations of BDNF levels or neuronal plasticity in MDD patients before and after antidepressant treatment can be measured through the examination of serum or plasma BDNF concentrations. BDNF levels can therefore be useful markers for clinical response or improvement of depressive symptoms, but they are not diagnostic markers of major depression.
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影响因子：
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作者：
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