Advances in imaging ultrastructure yield new insights into presynaptic biology.
Advances in imaging ultrastructure yield new insights into presynaptic biology.
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DOI：
10.3389/fncel.2015.00196
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发表时间：
2015
影响因子：
5.3
通讯作者：
O'Connor-Giles KM
中科院分区：
文献类型：
--
作者：
Bruckner JJ;Zhan H;O'Connor-Giles KM
突触是神经回路的基本功能单位，其失调与多种神经系统疾病有关。在突触前末梢，充满神经递质的突触小泡响应钙流入而释放，通过动作电位的到达激活的电压门控钙通道。数十年的电生理学、生物化学和遗传学研究促进了人们对突触前生物学的日益深入的了解。成像研究正在对突触如何组织以执行其关键功能产生新的见解。用于电子显微镜 (EM) 的神经元组织快速固定和保存技术的发展导致了超微结构成像的新复兴，迅速增进了我们对突触结构和功能的理解。
Synapses are the fundamental functional units of neural circuits, and their dysregulation has been implicated in diverse neurological disorders. At presynaptic terminals, neurotransmitter-filled synaptic vesicles are released in response to calcium influx through voltage-gated calcium channels activated by the arrival of an action potential. Decades of electrophysiological, biochemical, and genetic studies have contributed to a growing understanding of presynaptic biology. Imaging studies are yielding new insights into how synapses are organized to carry out their critical functions. The development of techniques for rapid immobilization and preservation of neuronal tissues for electron microscopy (EM) has led to a new renaissance in ultrastructural imaging that is rapidly advancing our understanding of synapse structure and function.
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影响因子：
3
作者：
Agronskaia, Alexandra V.;Valentijn, Jack A.;Gerritsen, Hans C.
通讯作者：
Gerritsen, Hans C.
影响因子：
56.9
作者：
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通讯作者：
SCHELLER, RH
影响因子：
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作者：
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5.3
作者：
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通讯作者：
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影响因子：
5.3
作者：
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通讯作者：
Young, Samuel M., Jr.