Adult age differences in functional connectivity during executive control.
Adult age differences in functional connectivity during executive control.
复制标题
DOI：
10.1016/j.neuroimage.2010.04.249
复制
发表时间：
2010-08-15
期刊：
影响因子：
5.7
通讯作者：
Cabeza, Roberto
中科院分区：
文献类型：
--
作者：
Madden, David J.;Costello, Matthew C.;Dennis, Nancy A.;Davis, Simon W.;Shepler, Anne M.;Spaniol, Julia;Bucur, Barbara;Cabeza, Roberto
任务切换需要执行控制过程，该过程会随着年龄的增长而下降。先前的神经影像学研究已经确定了与全局切换效应（双任务块与单任务块）相关的大脑激活的年龄相关差异，但尚未研究局部切换效应（块内的切换试验与重复试验）过程中与年龄相关的激活差异。该实验使用功能磁共振成像（fMRI）和扩散张量成像（DTI）来检查相邻试验之间任务切换（即局部任务切换）的成人年龄差异。在功能磁共振成像扫描期间，参与者执行了提示性的单词分类任务。从散布的仅提示试验中，与提示相关的开关相关处理是与目标分开估计的。在分布式额顶叶网络中，与任务切换相关的激活对于提示相关和目标相关的处理是不同的。对于年轻人（n = 20；18-27 岁）和老年人（n = 20；60-85 岁），任务切换的事件相关激活程度相似，尽管在整个任务期间持续的激活表现出一些与年龄相关的下降。至关重要的是，在提示处理过程中，年轻人的开关相关区域的功能连接性高于老年人，而目标处理过程中的功能连接性在不同年龄组中具有可比性。此外，与提示相关的功能连接的个体差异在目标分类反应效率（漂移率）方面与年龄相关的变异性有很大一部分相同。然而，这种与年龄相关的功能连接差异与任务相关区域内的白质完整性无关。这些发现强调了额顶叶激活的功能连接是与年龄相关的执行控制能力下降的潜在根源。
Task switching requires executive control processes that undergo age-related decline. Previous neuroimaging studies have identified age-related differences in brain activation associated with global switching effects (dual-task blocks vs. single-task blocks), but age-related differences in activation during local switching effects (switch trials vs. repeat trials, within blocks) have not been investigated. This experiment used functional magnetic resonance imaging (fMRI), and diffusion tensor imaging (DTI), to examine adult age differences in task switching across adjacent trials (i.e., local task switching). During fMRI scanning, participants performed a cued, word categorization task. From interspersed cue-only trials, switch-related processing associated with the cue was estimated separately from the target. Activation associated with task switching, within a distributed frontoparietal network, differed for cue- and target-related processing. The magnitude of event-related activation for task switching was similar for younger adults (n = 20; 18-27 years) and older adults (n = 20; 60-85 years), although activation sustained throughout the on-tasks periods exhibited some age-related decline. Critically, the functional connectivity of switch-related regions, during cue processing, was higher for younger adults than for older adults, whereas functional connectivity during target processing was comparable across the age groups. Further, individual differences in cue-related functional connectivity shared a substantial portion of the age-related variability in the efficiency of target categorization response (drift rate). This age-related difference in functional connectivity, however, was independent of white matter integrity within task-relevant regions. These findings highlight the functional connectivity of frontoparietal activation as a potential source of age-related decline in executive control.
登录
查看更多内容
影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
影响因子：
3.7
作者：
Davis, Simon W.;Dennis, Nancy A.;Cabeza, Roberto
通讯作者：
Cabeza, Roberto
影响因子：
5.7
作者：
Donaldson, DI;Petersen, SE;Buckner, RL
通讯作者：
Buckner, RL
衰老对成功项目和源存储器编码的神经相关性的影响。
DOI：
10.1037/0278-7393.34.4.791
发表时间：
2008-07
期刊：
Journal of experimental psychology. Learning, memory, and cognition
影响因子：
--
作者：
Dennis NA;Hayes SM;Prince SE;Madden DJ;Huettel SA;Cabeza R
通讯作者：
Cabeza R
影响因子：
3.7
作者：
Barber, AD;Carter, CS
通讯作者：
Carter, CS