Serum leptin levels and energy expenditure in normal weight women.
Serum leptin levels and energy expenditure in normal weight women.
复制标题
正常体重女性的血清瘦素水平和能量消耗。
DOI：
10.1139/y98-006
复制
发表时间：
1998
影响因子：
2.1
通讯作者：
J. Caro
中科院分区：
文献类型：
--
作者：
L. Martin;Pjh Jones;R. Considine;W. Su;N. Boyd;J. Caro
为了研究健康人群中循环瘦素水平是否与能量消耗相关，对27名女性（平均年龄48.6岁，体重61.9 kg，体重指数23.2）进行了双标水能测量和食物摄入评估。测定13天内的能量消耗。通过7天的饮食记录来测量食物摄入量。用放射免疫法测定瘦素。瘦素水平与体脂率（r = 0.59; p < 0.001）、脂肪量（r = 0.60; p < 0.001）和体重指数（r = 0.41; p = 0.03）密切相关，但与能量消耗无相关性（r = 0.02; p = 0.93）。在控制体脂率后，瘦素水平与能量消耗呈显著正相关（p = 0.06）。年龄、体力活动、瘦体重、身高或饮食变量与瘦素水平没有显著的单变量关联。当控制体脂时，观察到碳水化合物能量百分比与饮食脂肪和酒精摄入量呈显著正相关，负相关。这些发现证实了先前瘦素与体脂含量之间的关联，并提示健康人血清瘦素与能量消耗水平之间的关系。
To investigate whether circulating leptin levels are associated with energy expenditure in healthy humans, doubly labeled water energy measurements and food intake assessment were carried out in 27 women (mean age, 48.6 years; weight, 61.9 kg; body mass index, 23.2). Energy expenditure was determined over 13 days. Food intake was measured by 7-day food records. Leptin was measured by radioimmunoassay. Leptin level was strongly associated with percentage body fat (r = 0.59; p < 0.001), fat mass (r = 0.60; p < 0.001), and body mass index (r = 0.41; p = 0.03), but no correlation was observed with energy expenditure (r = 0.02; p = 0.93). After controlling for percentage body fat, a positive association of leptin level with energy expenditure of marginal significance (p = 0.06) was observed. There were no significant univariate associations of age, physical activity, lean body mass, height, or dietary variables with leptin level. When controlling for body fat, a significant positive correlation was observed for percent energy from carbohydrate and negative correlations with dietary fat and alcohol intake. These findings confirm previous associations between leptin and body fat content and suggest a relationship between serum leptin and energy expenditure level in healthy humans.
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DOI：
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发表时间：
--
期刊：
--
影响因子：
--
作者：
通讯作者：
--
影响因子：
7.1
作者：
BANDINI, LG;SCHOELLER, DA;DIETZ, WH
通讯作者：
DIETZ, WH
影响因子：
--
作者：
SCHOELLER, DA;RAVUSSIN, E;JEQUIER, E
通讯作者：
JEQUIER, E
影响因子：
56.9
作者：
HALAAS, JL;GAJIWALA, KS;FRIEDMAN, JM
通讯作者：
FRIEDMAN, JM
影响因子：
158.5
作者：
Considine, RV;Sinha, MK;Caro, JF
通讯作者：
Caro, JF