Priming dendritic cells for th2 polarization: lessons learned from helminths and implications for metabolic disorders.
Priming dendritic cells for th2 polarization: lessons learned from helminths and implications for metabolic disorders.
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DOI：
10.3389/fimmu.2014.00499
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发表时间：
2014
影响因子：
7.3
通讯作者：
Guigas B
中科院分区：
文献类型：
--
作者：
Hussaarts L;Yazdanbakhsh M;Guigas B
世界上近四分之一的人口感染了蠕虫寄生虫。蠕虫感染的一个共同特征是 2 型免疫反应的表现，其特征是介导抗蠕虫免疫的辅助 T 2 (Th2) 细胞。此外，最近的文献描述了 2 型免疫反应与伤口修复之间的密切关联，表明 Th2 反应可能同时介导寄生虫引起的损伤的修复。尽管树突状细胞 (DC)（免疫系统中最有效的抗原呈递细胞）发挥着核心作用，但人们对控制 Th2 反应的分子机制知之甚少。在这里，我们回顾了 DC 极化 Th2 细胞的分子机制，检查了蠕虫抗原和蠕虫介导的组织损伤作为 Th2 诱导触发因素。最后，我们讨论了这些发现在代谢紊乱背景下的意义，因为最近的文献表明 Th2 相关炎症反应的各个方面都有助于代谢稳态。
Nearly one quarter of the world’s population is infected with helminth parasites. A common feature of helminth infections is the manifestation of a type 2 immune response, characterized by T helper 2 (Th2) cells that mediate anti-helminth immunity. In addition, recent literature describes a close association between type 2 immune responses and wound repair, suggesting that a Th2 response may concurrently mediate repair of parasite-induced damage. The molecular mechanisms that govern Th2 responses are poorly understood, although it is clear that dendritic cells (DCs), which are the most efficient antigen-presenting cells in the immune system, play a central role. Here, we review the molecular mechanisms by which DCs polarize Th2 cells, examining both helminth antigens and helminth-mediated tissue damage as Th2-inducing triggers. Finally, we discuss the implication of these findings in the context of metabolic disorders, as recent literature indicates that various aspects of the Th2-associated inflammatory response contribute to metabolic homeostasis.
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DOI：
10.1084/jem.182.5.1591
发表时间：
1995-11-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Constant S;Pfeiffer C;Woodard A;Pasqualini T;Bottomly K
通讯作者：
Bottomly K
影响因子：
15.3
作者：
Bonifaz, L;Bonnyay, D;Mahnke, K;Rivera, M;Nussenzweig, MC;Steinman, RM
通讯作者：
Steinman, RM
影响因子：
3.8
作者：
Aravindhan V;Mohan V;Surendar J;Muralidhara Rao M;Pavankumar N;Deepa M;Rajagopalan R;Kumaraswami V;Nutman TB;Babu S
通讯作者：
Babu S
影响因子：
7.3
作者：
Arima K;Watanabe N;Hanabuchi S;Chang M;Sun SC;Liu YJ
通讯作者：
Liu YJ
影响因子：
82.9
作者：
通讯作者：
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