Weekly monitoring of children with asthma for infections and illness during common cold seasons.
Weekly monitoring of children with asthma for infections and illness during common cold seasons.
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DOI：
10.1016/j.jaci.2010.01.059
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发表时间：
2010-05
影响因子：
14.2
通讯作者：
Gern, James E.
中科院分区：
文献类型：
--
作者：
Olenec, Jaime P.;Kim, Woo Kyung;Lee, Wai-Ming;Vang, Fue;Pappas, Tressa E.;Salazar, Lisa E. P.;Evans, Michael D.;Bork, Jack;Roberg, Kathleen;Lemanske, Robert F., Jr.;Gern, James E.
关键词：
儿童哮喘和鼻病毒感染的恶化均在春季和秋季达到高峰，表明病毒感染是季节性哮喘发病的主要原因。我们试图评估哮喘儿童高峰季节的鼻病毒感染，并分析病毒感染与疾病严重程度之间的关系。 58 名 6 至 8 岁哮喘儿童在 9 月和 4 月期间每周提供连续 5 次鼻腔灌洗样本；记录症状、药物使用和峰值流量。通过多重 PCR 和病毒基因组部分测序来鉴定鼻病毒。 36%至50%的标本中检出病毒，其中72%至99%的病毒是鼻病毒。 169株鼻病毒分离株中有52株（其中16株为人鼻病毒C型）；超过2个收集期均未发现菌株，除2名儿童外，所有儿童均出现呼吸道感染。病毒阳性周与感冒和哮喘症状严重程度相关（分别为 P < .0001 和 P = .0002）。此外，病毒阳性疾病会增加感冒和哮喘症状的持续时间和严重程度，并且更频繁地导致哮喘失控（47% vs 22%，P = .008）。尽管过敏原敏感儿童与非过敏儿童的病毒感染数量相同，但前者有症状的病毒性疾病多出 47%（每月 1.19 例 vs 0.81 例，P = .03）。在普通寒冷季节，鼻病毒感染在哮喘儿童中几乎普遍存在，这可能是因为每个季节都会出现大量新病毒株。与病毒相关的疾病持续时间更长、更严重。最后，特应性哮喘儿童经历更频繁和更严重的病毒引起的疾病。
Exacerbations of childhood asthma and rhinovirus infections both peak during the spring and fall, suggesting that viral infections are major contributors to seasonal asthma morbidity. We sought to evaluate rhinovirus infections during peak seasons in children with asthma and to analyze relationships between viral infection and illness severity. Fifty-eight children aged 6 to 8 years with asthma provided 5 consecutive weekly nasal lavage samples during September and April; symptoms, medication use, and peak flow were recorded. Rhinoviruses were identified by using multiplex PCR and partial sequencing of viral genomes. Viruses were detected in 36% to 50% of the specimens, and 72% to 99% of the viruses were rhinoviruses. There were 52 different strains (including 16 human rhinovirus C) among the 169 rhinovirus isolates; no strains were found in more than 2 collection periods, and all but 2 children had a respiratory tract infection. Virus-positive weeks were associated with greater cold and asthma symptom severity (P < .0001 and P = .0002, respectively). Furthermore, virus-positive illnesses had increased duration and severity of cold and asthma symptoms and more frequent loss of asthma control (47% vs 22%, P = .008). Although allergen-sensitized versus nonsensitized children had the same number of viral infections, the former had 47% more symptomatic viral illnesses (1.19 vs 0.81 per month, P = .03). Rhinovirus infections are nearly universal in children with asthma during common cold seasons, likely because of a plethora of new strains appearing each season. Illnesses associated with viruses have greater duration and severity. Finally, atopic asthmatic children experienced more frequent and severe virus-induced illnesses.
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DOI：
10.1016/j.jaci.2008.10.007
发表时间：
2009-01
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Miller EK;Edwards KM;Weinberg GA;Iwane MK;Griffin MR;Hall CB;Zhu Y;Szilagyi PG;Morin LL;Heil LH;Lu X;Williams JV;New Vaccine Surveillance Network
通讯作者：
New Vaccine Surveillance Network
影响因子：
6.4
作者：
MONTO, AS;BRYAN, ER;OHMIT, S
通讯作者：
OHMIT, S
DOI：
10.1016/j.jcv.2007.03.012
发表时间：
2007-06
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
McErlean P;Shackelton LA;Lambert SB;Nissen MD;Sloots TP;Mackay IM
通讯作者：
Mackay IM
DOI：
10.1164/ajrccm.159.3.9801052
发表时间：
1999-03-01
影响因子：
24.7
作者：
Rakes, CP;Arruda, E;Heymann, PW
通讯作者：
Heymann, PW
影响因子：
10
作者：
Murray, CS;Poletti, G;Custovic, A
通讯作者：
Custovic, A