An endogenous foamy-like viral element in the coelacanth genome.
An endogenous foamy-like viral element in the coelacanth genome.
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DOI：
10.1371/journal.ppat.1002790
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发表时间：
2012
期刊：
影响因子：
6.7
通讯作者：
Worobey M
中科院分区：
文献类型：
--
作者：
Han GZ;Worobey M
目前对逆转录病毒的起源和长期进化模式知之甚少。逆转录病毒可以整合到宿主的基因组中，为研究它们的深层历史提供了分子化石记录。在这里，我们报告的内源性泡沫病毒样元素的发现，我们指定的“腔棘鱼内源性泡沫样病毒”（CoeEFV），在腔棘鱼（Latimeria chalumenum）的基因组内。系统发育分析将CoeEFV置于所有已知泡沫病毒的基础，强烈表明这种主要逆转录病毒谱系的古老海洋起源，以前已知仅感染陆地哺乳动物。CoeEFV的发现揭示了泡沫样病毒在哺乳动物以外的物种中的存在。我们表明，泡沫状病毒可能与脊椎动物宿主共分化了4.07亿多年，并与脊椎动物宿主一起经历了从水到陆地的进化过渡。这些发现表明逆转录病毒起源于古代海洋，对理解泡沫病毒生物学具有重要意义。逆转录病毒的深层历史仍然不清楚。逆转录病毒可以在宿主的基因组中留下完整的拷贝，为研究它们的长期进化提供化石记录。内源性泡沫病毒是一种复杂的逆转录病毒，已知只感染哺乳动物物种，似乎非常罕见，迄今为止只在树懒和指狐猴中发现。在这里，我们报告发现内源性泡沫病毒样插入的基因组内的一个所谓的“活化石”，腔棘鱼（Latimeria chaluminensis）。我们提供的证据表明，泡沫病毒和它们的宿主有着超过4.07亿年的共同进化历史，泡沫病毒伴随着它们的脊椎动物宿主从水到陆地的进化过渡。这些发现表明，逆转录病毒起源于数百万年前的原始海洋。
Little is known about the origin and long-term evolutionary mode of retroviruses. Retroviruses can integrate into their hosts' genomes, providing a molecular fossil record for studying their deep history. Here we report the discovery of an endogenous foamy virus-like element, which we designate ‘coelacanth endogenous foamy-like virus’ (CoeEFV), within the genome of the coelacanth (Latimeria chalumnae). Phylogenetic analyses place CoeEFV basal to all known foamy viruses, strongly suggesting an ancient ocean origin of this major retroviral lineage, which had previously been known to infect only land mammals. The discovery of CoeEFV reveals the presence of foamy-like viruses in species outside the Mammalia. We show that foamy-like viruses have likely codiverged with their vertebrate hosts for more than 407 million years and underwent an evolutionary transition from water to land with their vertebrate hosts. These findings suggest an ancient marine origin of retroviruses and have important implications in understanding foamy virus biology. The deep history of retroviruses is still obscure. Retroviruses can leave integrated copies within their hosts' genomes, providing a fossil record for studying their long-term evolution. Endogenous forms of foamy viruses, complex retroviruses known to infect only mammalian species, appear to be extremely rare, so far found only in sloths and the aye-aye. Here, we report the discovery of endogenous foamy virus-like insertions within the genome of a so-called ‘living fossil’, the coelacanth (Latimeria chalumnae). We provide evidence suggesting that foamy viruses and their hosts share a coevolutionary history of more than 407 million years, and that foamy viruses accompanied their vertebrate hosts on the evolutionary transition from water to land. These findings indicate that the retroviruses originated in the primeval ocean millions of years ago.
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影响因子：
5.9
作者：
Patel, Maulik R.;Emerman, Michael;Malik, Harmit S.
通讯作者：
Malik, Harmit S.
影响因子：
9.8
作者：
Drummond AJ;Ho SY;Phillips MJ;Rambaut A
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Rambaut A
影响因子：
4.5
作者：
Gilbert C;Maxfield DG;Goodman SM;Feschotte C
通讯作者：
Feschotte C
影响因子：
30.3
作者：
Holmes EC
通讯作者：
Holmes EC
影响因子：
10.7
作者：
Posada, David
通讯作者：
Posada, David