Availability of food determines the need for sleep in memory consolidation.
Availability of food determines the need for sleep in memory consolidation.
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食物的可用性决定了记忆巩固中睡眠的需求。
DOI：
10.1038/s41586-020-2997-y
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发表时间：
2021-01
期刊：
影响因子：
64.8
通讯作者：
Sehgal A
中科院分区：
文献类型：
--
作者：
Chouhan NS;Griffith LC;Haynes P;Sehgal A
Sleep remains a major mystery of biology, with little understood about its basic function. One of the most commonly proposed functions for sleep is the consolidation of memory. However, as conditions like starvation require the organism to be awake and active, the ability to switch to a memory consolidation mechanism that is not contingent on sleep may confer an evolutionary advantage. Here, we identify a novel adaptive circuit-based mechanism that enables Drosophila to form sleep-dependent and sleep-independent memory. Flies fed after appetitive conditioning needed increased sleep for memory consolidation, but flies starved after training did not require sleep to form memories. Memory in fed flies is mediated by the anterior-posterior α’/β’ neurons of the mushroom body (MB), while memory under starvation is mediated by medial α’/β’ neurons. Sleep-dependent and sleep-independent memory rely upon distinct dopaminergic neurons and corresponding MB output neurons. However, sleep and memory are coupled such that mushroom body neurons required for sleep-dependent memory also promote sleep. Flies lacking Neuropeptide F display sleep-dependent memory even when starved, suggesting that circuit selection is determined by hunger. This plasticity in memory circuits enables flies to retain essential information in changing environments.
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影响因子：
7.7
作者：
Aso Y;Hattori D;Yu Y;Johnston RM;Iyer NA;Ngo TT;Dionne H;Abbott LF;Axel R;Tanimoto H;Rubin GM
通讯作者：
Rubin GM
影响因子：
2.1
作者：
Aly, Mariam;Moscovitch, Morris
通讯作者：
Moscovitch, Morris
影响因子：
9.2
作者：
Burke, Christopher J.;Waddell, Scott
通讯作者：
Waddell, Scott
DOI：
10.1016/j.cub.2015.09.017
发表时间：
2015-11-16
期刊：
Current biology : CB
影响因子：
--
作者：
Sitaraman D;Aso Y;Jin X;Chen N;Felix M;Rubin GM;Nitabach MN
通讯作者：
Nitabach MN
DOI：
10.1016/j.cub.2010.05.029
发表时间：
2010-07-13
期刊：
Current biology : CB
影响因子：
--
作者：
Keene AC;Duboué ER;McDonald DM;Dus M;Suh GS;Waddell S;Blau J
通讯作者：
Blau J