Estrogens and the regulation of glucose metabolism.
Estrogens and the regulation of glucose metabolism.
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DOI：
10.4239/wjd.v12.i10.1622
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发表时间：
2021-10-15
影响因子：
4.2
通讯作者：
Alemany M
中科院分区：
文献类型：
--
作者：
Alemany M
主要的雌激素：雌二醇、雌酮及其酰基酯的研究基本上与它们的经典雌激素和药理功能有关。然而，它们在体内的主要作用可能是持续控制核心能量代谢。雌激素核受体和膜受体在调节代谢反应方面表现出非凡的灵活性，并在很大程度上解释了能量代谢的性别和年龄差异：这些机制的一部分已经被充分了解，可以证明两者的合理性。在能量方面，雌激素分子种主要通过以下四个关键功能发挥作用：(1)促进胰岛素分泌和控制葡萄糖供应；(2)调节能量分配，当脂质比碳水化合物更有效时，更倾向于利用脂质作为主要的能量底物；(3)通过抗氧化机制实现功能保护；(4)中枢效应（主要通过神经调节）对全身能量管理的影响。分析了雌酮、雌二醇及其酰基酯的不同作用，提出了基于结构/作用的初步分类。无论是单独还是作为一个群体，雌激素都提供了一个全面的解释，即并非它们所有的各种各样的作用都仅仅与特定的分子有关。作为一个群体，它们构成了一个强大的协同作用综合体。因此，雌激素可以被认为是能量稳态的守护者。
The main estrogens: estradiol, estrone, and their acyl-esters have been studied essentially related to their classical estrogenic and pharmacologic functions. However, their main effect in the body is probably the sustained control of core energy metabolism. Estrogen nuclear and membrane receptors show an extraordinary flexibility in the modulation of metabolic responses, and largely explain gender and age differences in energy metabolism: part of these mechanisms is already sufficiently known to justify both. With regard to energy, the estrogen molecular species act essentially through four key functions: (1) Facilitation of insulin secretion and control of glucose availability; (2) Modulation of energy partition, favoring the use of lipid as the main energy substrate when more available than carbohydrates; (3) Functional protection through antioxidant mechanisms; and (4) Central effects (largely through neural modulation) on whole body energy management. Analyzing the different actions of estrone, estradiol and their acyl esters, a tentative classification based on structure/effects has been postulated. Either separately or as a group, estrogens provide a comprehensive explanation that not all their quite diverse actions are related solely to specific molecules. As a group, they constitute a powerful synergic action complex. In consequence, estrogens may be considered wardens of energy homeostasis.
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影响因子：
2.9
作者：
ANANTHARAMANBARR, HG;DECOMBAZ, J
通讯作者：
DECOMBAZ, J
雌激素受体ERα调节胰腺胰岛素含量。
影响因子：
3.7
作者：
Alonso-Magdalena, Paloma;Ropero, Ana B.;Carrera, M. Pilar;Cederroth, Christopher R.;Baquie, Mathurin;Gauthier, Benoit R.;Nef, Serge;Stefani, Enrico;Nadal, Angel
通讯作者：
Nadal, Angel
影响因子：
4.9
作者：
Bennink, HJTC
通讯作者：
Bennink, HJTC
影响因子：
7.3
作者：
Bereshchenko O;Bruscoli S;Riccardi C
通讯作者：
Riccardi C
影响因子：
3.7
作者：
Arriaran, Sofia;Agnelli, Silvia;Alemany, Maria
通讯作者：
Alemany, Maria