Sporadic premature aging in a Japanese monkey: a primate model for progeria.
Sporadic premature aging in a Japanese monkey: a primate model for progeria.
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日本猴子中零星的过早衰老：一种纪念的灵长类动物模型。
DOI：
10.1371/journal.pone.0111867
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Takada M
中科院分区：
文献类型：
--
作者：
Oishi T;Imai H;Go Y;Imamura M;Hirai H;Takada M
我们研究所最近发现了一只小日本猴，其特征是皮肤有很深的皱纹，双眼患有白内障。进行了大量的分析来识别代表衰老不同方面的症状。在这只猴子中，与正常对照相比，早期传代的成纤维细胞的细胞周期显着延长。此外，还观察到衰老细胞的出现和DNA修复的缺陷。此外，病理检查显示该猴患有皮肤异色症并伴有浅表毛细血管扩张，生化检测证实HbA1c和尿透明质酸水平高于其他（儿童、成年和老年）猴组。特别有趣的是，我们的 MRI 分析显示，脑沟和侧脑室的扩张可能是由于大脑皮层和海马体的收缩所致。此外，外周感觉神经而非运动神经的传导速度低于成年猴和幼猴，并且与老年猴一样低。然而，我们无法检测到导致主要早衰综合症的已知基因的任何个体独特突变。目前的结果表明，猴子患有一种早衰症，这种早衰症不一定是人类早衰综合症的典型症状。
In our institute, we have recently found a child Japanese monkey who is characterized by deep wrinkles of the skin and cataract of bilateral eyes. Numbers of analyses were performed to identify symptoms representing different aspects of aging. In this monkey, the cell cycle of fibroblasts at early passage was significantly extended as compared to a normal control. Moreover, both the appearance of senescent cells and the deficiency in DNA repair were observed. Also, pathological examination showed that this monkey has poikiloderma with superficial telangiectasia, and biochemical assay confirmed that levels of HbA1c and urinary hyaluronan were higher than those of other (child, adult, and aged) monkey groups. Of particular interest was that our MRI analysis revealed expansion of the cerebral sulci and lateral ventricles probably due to shrinkage of the cerebral cortex and the hippocampus. In addition, the conduction velocity of a peripheral sensory but not motor nerve was lower than in adult and child monkeys, and as low as in aged monkeys. However, we could not detect any individual-unique mutations of known genes responsible for major progeroid syndromes. The present results indicate that the monkey suffers from a kind of progeria that is not necessarily typical to human progeroid syndromes.
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DOI：
10.1073/pnas.92.20.9363
发表时间：
1995-09-26
影响因子：
11.1
作者：
DIMRI, GP;LEE, XH;CAMPISI, J
通讯作者：
CAMPISI, J
影响因子：
2.5
作者：
Marigliano, Marco;Casu, Anna;Bottino, Rita
通讯作者：
Bottino, Rita
DOI：
10.1016/s1357-2725(02)00039-0
发表时间：
2002-11-01
影响因子：
4
作者：
Mohaghegh, P;Hickson, ID
通讯作者：
Hickson, ID
影响因子：
5.3
作者：
Goto, M
通讯作者：
Goto, M
影响因子：
2.8
作者：
Nishimura, Takeshi;Oishi, Takao;Takahashi, Toshimitsu
通讯作者：
Takahashi, Toshimitsu